Source:http://linkedlifedata.com/resource/pubmed/id/17951971
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2007-10-22
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| pubmed:abstractText |
Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between oxidative DNA damage and MBOCA exposure. In addition, we examined the effects of different confounders on the plasma level of 8-OHdG. We undertook a cross-sectional survey at four MBOCA-producing factories in Taiwan (158 subjects). Plasma 8-OHdG levels and urinary MBOCA concentrations were measured by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). Personal characteristics were collected by questionnaire. The workers were classified according to their job titles as exposed (n=57) or unexposed (n=101) groups as well as classified according to urinary MBOCA levels as high urinary MBOCA (>20 microg/g creatinine) (n=45) or low urinary MBOCA (n=108) groups. Neither the MBOCA-exposed workers nor the high urinary MBOCA workers had a significant increase in the mean plasma 8-OHdG level, even after adjustment for potential confounders. Age and gender were significantly positively correlated with plasma 8-OHdG levels. Smokers among high urinary MBOCA workers also had significantly higher 8-OHdG levels than non-smokers among high urinary MBOCA workers. Our study provides evidence that smoking rather than MBOCA exposure induces elevation of plasma 8-OHdG levels among workers exposed to MBOCA, indicating that oxidative DNA damage does not play an important role in the carcinogenic processes of MBOCA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-hydroxy-2'-deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Air Pollutants, Occupational,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Methylenebis(chloroaniline)
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1341-9145
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
49
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
389-98
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| pubmed:meshHeading |
pubmed-meshheading:17951971-Adult,
pubmed-meshheading:17951971-Age Distribution,
pubmed-meshheading:17951971-Air Pollutants, Occupational,
pubmed-meshheading:17951971-Alcohol Drinking,
pubmed-meshheading:17951971-Biological Markers,
pubmed-meshheading:17951971-Body Mass Index,
pubmed-meshheading:17951971-Chromatography, Liquid,
pubmed-meshheading:17951971-Confounding Factors (Epidemiology),
pubmed-meshheading:17951971-Cross-Sectional Studies,
pubmed-meshheading:17951971-DNA Damage,
pubmed-meshheading:17951971-Deoxyguanosine,
pubmed-meshheading:17951971-Dose-Response Relationship, Drug,
pubmed-meshheading:17951971-Humans,
pubmed-meshheading:17951971-Linear Models,
pubmed-meshheading:17951971-Male,
pubmed-meshheading:17951971-Methylenebis(chloroaniline),
pubmed-meshheading:17951971-Middle Aged,
pubmed-meshheading:17951971-Occupational Exposure,
pubmed-meshheading:17951971-Oxidative Stress,
pubmed-meshheading:17951971-Questionnaires,
pubmed-meshheading:17951971-Sex Distribution,
pubmed-meshheading:17951971-Smoking,
pubmed-meshheading:17951971-Taiwan
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| pubmed:year |
2007
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| pubmed:articleTitle |
Oxidative DNA damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): influence of 4, 4'-methylenebis (2-chloroaniline) exposure and smoking.
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| pubmed:affiliation |
Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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