| pubmed-article:17950773 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17950773 | lifeskim:mentions | umls-concept:C0037355 | lld:lifeskim |
| pubmed-article:17950773 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:17950773 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:17950773 | lifeskim:mentions | umls-concept:C1812609 | lld:lifeskim |
| pubmed-article:17950773 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17950773 | pubmed:dateCreated | 2008-1-15 | lld:pubmed |
| pubmed-article:17950773 | pubmed:abstractText | The viral strain responsible for smallpox infection is variola major (VARV). As a result of the successful eradication of smallpox with the vaccinia virus (VACV), the general population is no longer required to receive a smallpox vaccine, and will have no protection against smallpox. This lack of immunity is a concern due to the potential for use of smallpox as a biological weapon. Considerable progress has been made in the development of subunit-based smallpox vaccines resulting from the identification of VACV protective antigens. It also offers the possibility of using antigens from VARV to formulate the next generation subunit-based smallpox vaccines. Here, we show that codon-optimized DNA vaccines expressing three VARV antigens (A30, B7 and F8) and their recombinant protein counterparts elicited high-titer, cross-reactive, VACV neutralizing antibody responses in mice. Vaccinated mice were protected from intraperitoneal and intranasal challenges with VACV. These results suggest the feasibility of a subunit smallpox vaccine based on VARV antigen sequences to induce immunity against poxvirus infection. | lld:pubmed |
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| pubmed-article:17950773 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17950773 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950773 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17950773 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17950773 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17950773 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17950773 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:17950773 | pubmed:author | pubmed-author:SeulBB | lld:pubmed |
| pubmed-article:17950773 | pubmed:author | pubmed-author:ZhangChuanyou... | lld:pubmed |
| pubmed-article:17950773 | pubmed:author | pubmed-author:WangShixiaS | lld:pubmed |
| pubmed-article:17950773 | pubmed:author | pubmed-author:SakhatskyyPav... | lld:pubmed |
| pubmed-article:17950773 | pubmed:author | pubmed-author:ChouTe-HuiTH | lld:pubmed |
| pubmed-article:17950773 | pubmed:author | pubmed-author:KishkoMichael... | lld:pubmed |
| pubmed-article:17950773 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17950773 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:17950773 | pubmed:volume | 371 | lld:pubmed |
| pubmed-article:17950773 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17950773 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17950773 | pubmed:pagination | 98-107 | lld:pubmed |
| pubmed-article:17950773 | pubmed:dateRevised | 2011-5-4 | lld:pubmed |
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| pubmed-article:17950773 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17950773 | pubmed:articleTitle | Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens. | lld:pubmed |
| pubmed-article:17950773 | pubmed:affiliation | Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. | lld:pubmed |
