Linked Life Data

17950463

Source:http://linkedlifedata.com/resource/pubmed/id/17950463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-11-20
pubmed:abstractText
Sensory and environmental manipulations affect the development of sensory systems. Higher-order auditory representations (auditory categories or "objects") evolve with experience and via top-down influences modify representations in early auditory areas. During development of a functional auditory system, the capacity for bottom-up reorganizations is successively less well expressed due to a molecular change in synaptic properties. It is, however, complemented by top-down influences that direct and modulate the residual (adult) capacity for circuit reorganization. In a deprived condition, this developmental step is substantially affected. As higher-order representations cannot be established in absence of auditory experience, the developmental decrease in capacity for "bottom-up regulated" reorganizations (as repeatedly demonstrated in also in deprived sensory systems) cannot be complemented by an increasing influence of top-down modulations. In consequence, the ability to learn is compromised in sensory deprivation, resulting in a sensitive period for recovery.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0165-0173
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-69
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
What's to lose and what's to learn: development under auditory deprivation, cochlear implants and limits of cortical plasticity.
pubmed:affiliation
Laboratory of Auditory Neuroscience, Department of Neurophysiology and Pathophysiology, University of Hamburg School of Medicine, Germany. a.kral@uke.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural