Source:http://linkedlifedata.com/resource/pubmed/id/17950095
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2007-10-22
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pubmed:abstractText |
Adiponectin is a major adipocytokine and has been considered as an independent risk factor for arterial hypertension. Most studies on the subject have been restricted to biracial (white-black) and Asian groups. The present report examined whether adiponectin affects blood pressure in a sample of untreated obese Brazilians of multiethnic origin. Fasting plasma adiponectin and serum insulin were determined by radioimmunoassay. Insulin resistance was estimated by homeostatic model assessment of insulin resistance (HOMA-IR). Blood pressure was recorded using Dinamap 1846 (Critikon, Tampa, FL). Adiponectin was significantly lower in obese hypertensive individuals than in obese normotensive ones. Blood pressure, insulin, and HOMA-IR were significantly higher in obese hypertensive than in obese normotensive individuals. Plasma adiponectin was negatively associated with waist-to-hip ratio, blood pressure, insulin, and HOMA-IR. The comparison of obese individuals who markedly differed in their HOMA-IR (> vs <or=2.71) showed that the association of adiponectin and blood pressure remained significant only in obese insulin-resistant individuals, whose adiponectin showed a positive association with high-density lipoprotein cholesterol. Stepwise regression analysis revealed that HOMA-IR, adiponectin, body mass index, and age independently affected the risk for increased systolic blood pressure, with HOMA-IR the strongest of them all. Finally, when patients were stratified into tertiles of HOMA-IR and further classified according to the 50th percentile of adiponectin (<or= vs >6. 5 microg/mL), a 3 x 2 analysis of variance showed an independent contribution of adiponectin in the variation of mean arterial pressure. These results support the notion that HOMA-IR and adiponectin independently predict blood pressure variation in obese insulin-resistant Brazilians.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0026-0495
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1464-9
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pubmed:meshHeading |
pubmed-meshheading:17950095-Adiponectin,
pubmed-meshheading:17950095-Adolescent,
pubmed-meshheading:17950095-Adult,
pubmed-meshheading:17950095-Aged,
pubmed-meshheading:17950095-Brazil,
pubmed-meshheading:17950095-Female,
pubmed-meshheading:17950095-Humans,
pubmed-meshheading:17950095-Hypertension,
pubmed-meshheading:17950095-Insulin Resistance,
pubmed-meshheading:17950095-Male,
pubmed-meshheading:17950095-Middle Aged,
pubmed-meshheading:17950095-Obesity
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pubmed:year |
2007
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pubmed:articleTitle |
Hypoadiponectinemia is associated with blood pressure increase in obese insulin-resistant individuals.
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pubmed:affiliation |
Hypertension Clinic, Laboratory of Clinical and Experimental Pathophysiology, School of Medicine, Rio de Janeiro State University, RJ CEP 22221-090, Brazil. francischetti@globo.com
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pubmed:publicationType |
Journal Article
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