Linked Life Data

17950075

Source:http://linkedlifedata.com/resource/pubmed/id/17950075

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-10-22
pubmed:abstractText
In acute respiratory distress syndrome, pulmonary vascular permeability increases, causing intravascular fluid and protein to move into the lung's interstitium. The classic model describing the formation of pulmonary edema suggests that fluid crossing the capillary endothelium is drawn by negative interstitial pressure into the potential space surrounding extra-alveolar vessels and, as interstitial pressure builds, is forced into the alveolar air space. However, the validity of this model is challenged by animal models of acute lung injury in which extra-alveolar vessels are more permeable than capillaries under a variety of conditions. In the current study, we sought to determine whether extravascular fluid accumulation can be produced because of increased permeability of either the capillary or extra-alveolar endothelium, and whether different pathophysiology results from such site-specific increases in permeability.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-7
pubmed:meshHeading
pubmed-meshheading:17950075-Animals, pubmed-meshheading:17950075-Carcinogens, pubmed-meshheading:17950075-Cell Membrane Permeability, pubmed-meshheading:17950075-Disease Models, Animal, pubmed-meshheading:17950075-Endothelial Cells, pubmed-meshheading:17950075-Enzyme Inhibitors, pubmed-meshheading:17950075-Extravascular Lung Water, pubmed-meshheading:17950075-Lung, pubmed-meshheading:17950075-Lung Compliance, pubmed-meshheading:17950075-Male, pubmed-meshheading:17950075-Phorbol Esters, pubmed-meshheading:17950075-Pulmonary Alveoli, pubmed-meshheading:17950075-Pulmonary Edema, pubmed-meshheading:17950075-Rats, pubmed-meshheading:17950075-Rats, Sprague-Dawley, pubmed-meshheading:17950075-Respiratory Distress Syndrome, Adult, pubmed-meshheading:17950075-Respiratory Mechanics, pubmed-meshheading:17950075-Thapsigargin
pubmed:year
2007
pubmed:articleTitle
Phenotypic heterogeneity in lung capillary and extra-alveolar endothelial cells. Increased extra-alveolar endothelial permeability is sufficient to decrease compliance.
pubmed:affiliation
Center for Lung Biology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural