Linked Life Data

17949976

Source:http://linkedlifedata.com/resource/pubmed/id/17949976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2007-11-6
pubmed:abstractText
The design, synthesis, and antimalarial activity of chimeras of thiosemicarbazones (TSC) and ferroquine (FQ) is reported. Key structural elements derived from FQ were coupled to fragments capable of coordinating metal ions. Biological evaluation was conducted against four strains of the malaria parasite Plasmodium falciparum and against the parasitic cysteine protease falcipain-2. To establish the role of the ferrocenyl moiety in the antiplasmodial activity of this series, purely organic parent compounds were also synthesized and tested. The presence of the aminoquinoline structure, allowing transport of the compounds to the food vacuole of the parasite, seems to be the major contributor to antimalarial activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6434-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues.
pubmed:affiliation
Université des Sciences et Technologies, Unité de Catalyse et de Chimie du Solide-UMR CNRS 8181, ENSCL, Bâtiment C7, BP 90108, 59652 Villeneuve d'Ascq Cedex, France. christophe.biot@ensc-lille.fr
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural