Source:http://linkedlifedata.com/resource/pubmed/id/17949304
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-10-22
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| pubmed:abstractText |
There is an extremely high incidence of antimicrobial resistance of the clinical isolates of Staphylococcus aureus in Korea. This study carried out a molecular investigation to determine the prevalence of the community-associated antimicrobial-resistant S. aureus and methicillin-resistant S. aureus (MRSA). The percentage resistance from the nasal swabs of healthy volunteers in 2003 in Seoul is as follows: penicillin (91%), erythromycin (EM, 14%), gentamicin (GM, 9.3%), tetracycline (TE, 8.2%), cephalothin (4%), oxacillin (OX, MRSA; 3.8%), clindamycin (CC, 2.6%), ciprofloxacin (CIP, 0.8%), and sulfamethoxazole/trimethoprim (0.6%). The community-associated MRSA (C-MRSA) strains were examined by pulsed-field gel electrophoresis (PFGE) analysis of the SmaI macro-fragments, multilocus sequence typing (MLST), and staphylococcal cassette chromosome mec (SCCmec) typing using the PCR analysis. The Korean C-MRSA isolates were clustered into three distinct groups. One PFGE group containing the C-MRSA strains showed resistance to CC, EM, and GM, a high level (32-96 microg/ml) of resistance to methicillin, sequence type 5 (ST5), and SCCmec type II, which is the most common hospital associated-MRSA (H-MRSA) isolated in Korea. These results highlight the heterogeneous genetic background of the C-MRSA as well as the pervasiveness of the H-MRSA isolates in this community.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1076-6294
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
178-85
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:17949304-Adolescent,
pubmed-meshheading:17949304-Adult,
pubmed-meshheading:17949304-Anti-Bacterial Agents,
pubmed-meshheading:17949304-Bacterial Proteins,
pubmed-meshheading:17949304-Child,
pubmed-meshheading:17949304-Child, Preschool,
pubmed-meshheading:17949304-Community-Acquired Infections,
pubmed-meshheading:17949304-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:17949304-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:17949304-Humans,
pubmed-meshheading:17949304-Infant,
pubmed-meshheading:17949304-Infant, Newborn,
pubmed-meshheading:17949304-Korea,
pubmed-meshheading:17949304-Methicillin Resistance,
pubmed-meshheading:17949304-Microbial Sensitivity Tests,
pubmed-meshheading:17949304-Middle Aged,
pubmed-meshheading:17949304-Molecular Epidemiology,
pubmed-meshheading:17949304-Polymerase Chain Reaction,
pubmed-meshheading:17949304-Prevalence,
pubmed-meshheading:17949304-Sequence Analysis, DNA,
pubmed-meshheading:17949304-Staphylococcal Infections,
pubmed-meshheading:17949304-Staphylococcus aureus
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Molecular epidemiology of community-associated antimicrobial-resistant Staphylococcus aureus in Seoul, Korea (2003): pervasiveness of multidrug-resistant SCCmec type II methicillin-resistant S. aureus.
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| pubmed:affiliation |
Korea Food and Drug Administration, Seoul, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|