Linked Life Data

17948876

Source:http://linkedlifedata.com/resource/pubmed/id/17948876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-10-25
pubmed:abstractText
Activation of group II metabotropic glutamate receptors (mGluR2/3) in the amygdala plays a critical role in the regulation of fear and anxiety states. Previous studies using nonselective agonists have suggested this action can result from activation of either pre- or postsynaptic mGluR2/3. Here, we have used a combination of whole-cell patch clamp recording with highly selective agonists (LY354740 and LY379268) and immunoelectron microscopy to examine structure-function relationships for mGluR2/3 in the basolateral amygdala (BLA) and bed nucleus of the stria terminalis (BNST). Stimulation of mGluR2/3 evoked a direct, TTX-insensitive membrane hyperpolarization in all BLA projection neurons tested, but only about half of BNST neurons. The membrane hyperpolarization was mediated by activation of an outward potassium current or blockade of a tonically active inward I(h) current in different groups of BLA neurons. In both regions, mGluR2/3 caused a long-lasting reduction of glutamate release from presynaptic afferent terminals even at concentrations that failed to elicit a direct postsynaptic response. The localization of mGluR2/3 differed regionally, with postsynaptic labeling significantly more common in BLA than BNST, corresponding to the strength of postsynaptic responses recorded there. Our results demonstrate a complex role for mGluR2/3 receptors in modulating anxiety circuitry, including direct inhibition and reduction of excitatory drive. The combination of direct inhibition of projection neurons within the BLA and suppression of excitatory neurotransmission in the BNST may be responsible for the anxiolytic actions of group II mGluR agonists.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
505
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
682-700
pubmed:meshHeading
pubmed-meshheading:17948876-Amygdala, pubmed-meshheading:17948876-Animals, pubmed-meshheading:17948876-Anxiety Disorders, pubmed-meshheading:17948876-Electric Stimulation, pubmed-meshheading:17948876-Excitatory Amino Acid Agonists, pubmed-meshheading:17948876-Excitatory Postsynaptic Potentials, pubmed-meshheading:17948876-Glutamic Acid, pubmed-meshheading:17948876-Male, pubmed-meshheading:17948876-Membrane Potentials, pubmed-meshheading:17948876-Microscopy, Immunoelectron, pubmed-meshheading:17948876-Neural Inhibition, pubmed-meshheading:17948876-Neural Pathways, pubmed-meshheading:17948876-Organ Culture Techniques, pubmed-meshheading:17948876-Patch-Clamp Techniques, pubmed-meshheading:17948876-Potassium Channels, pubmed-meshheading:17948876-Presynaptic Terminals, pubmed-meshheading:17948876-Rats, pubmed-meshheading:17948876-Rats, Sprague-Dawley, pubmed-meshheading:17948876-Receptors, Metabotropic Glutamate, pubmed-meshheading:17948876-Septal Nuclei, pubmed-meshheading:17948876-Synaptic Transmission
pubmed:year
2007
pubmed:articleTitle
Group II metabotropic glutamate receptors in anxiety circuitry: correspondence of physiological response and subcellular distribution.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329, USA. ecmuly@rmy.emory.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural