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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
Combinatorial modifications of the core histones have the potential to fine-tune the epigenetic regulation of chromatin states. The Aurora B kinase is responsible for generating the double histone H3 modification tri-methylated K9/phosphorylated S10 (H3K9me3/S10ph), which has been implicated in chromosome condensation during mitosis. In this study, we have identified a novel role for Aurora B in epigenetic marking of silent chromatin during cell differentiation. We find that phosphorylation of H3 S10 by Aurora B generates high levels of the double H3K9me3/S10ph modification in differentiated postmitotic cells and also results in delocalisation of HP1beta away from heterochromatin in terminally differentiated plasma cells. Microarray analysis of the H3K9me3/S10ph modification shows a striking increase in the modification across repressed genes during differentiation of mesenchymal stem cells. Our results provide evidence that the Aurora B kinase has a role in marking silent chromatin independently of the cell cycle and suggest that targeting of Aurora B-mediated phosphorylation of H3 S10 to repressed genes could be a mechanism for epigenetic silencing of gene expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-10460410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-11242053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-11242054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-11387214,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-15713636,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-16506101,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-16769825,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-17199124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-17335352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-2849644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-6490006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-9362543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-9450992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-9636175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-9809983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17948062-9811564
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1460-2075
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4657-69
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pubmed:dateRevised |
2011-7-11
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pubmed:meshHeading |
pubmed-meshheading:17948062-Animals,
pubmed-meshheading:17948062-B-Lymphocytes,
pubmed-meshheading:17948062-Bone Marrow Cells,
pubmed-meshheading:17948062-Cell Differentiation,
pubmed-meshheading:17948062-Cell Line,
pubmed-meshheading:17948062-Cells, Cultured,
pubmed-meshheading:17948062-Epigenesis, Genetic,
pubmed-meshheading:17948062-Gene Silencing,
pubmed-meshheading:17948062-Heterochromatin,
pubmed-meshheading:17948062-Histones,
pubmed-meshheading:17948062-Mesenchymal Stem Cells,
pubmed-meshheading:17948062-Mice,
pubmed-meshheading:17948062-Mice, Inbred Strains,
pubmed-meshheading:17948062-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17948062-Phosphorylation,
pubmed-meshheading:17948062-Plasma Cells,
pubmed-meshheading:17948062-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17948062-Spleen
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pubmed:year |
2007
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