|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2007-11-27
|
|
pubmed:abstractText |
In Caenorhabditis elegans, sex is determined by the opposing actions of X-signal elements (XSEs) and autosomal signal elements (ASEs), which communicate the ratio of X chromosomes to sets of autosomes (X:A signal). This study delves more deeply into the mechanism by which XSEs transmit X chromosome dose. We determined the relative contributions of individual XSEs to the X:A signal and showed the order of XSE strength to be sex-1 > sex-2 > fox-1 > ceh-39 >/= region 1 XSE. sex-1 exerts a more potent influence on sex determination and dosage compensation than any other XSE by functioning in two separate capacities in the pathway: sex-1 acts upstream as an XSE to repress xol-1 and downstream as an activator of hermaphrodite development and dosage compensation. Furthermore, the process of dosage compensation affects expression of the very XSEs that control it; XSEs become fully dosage compensated once sex is determined. The X:A signal is then equivalent between XO and XX animals, causing sexual differentiation to be controlled by genes downstream of xol-1 in the sex-determination pathway. Prior to the onset of dosage compensation, the difference in XSE expression between XX and XO embryos appears to be greater than twofold, making X chromosome counting a robust process.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-10364546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-10388819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-11937488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-14976312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-15719061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-16139225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-17122774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-1716965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-17248881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-17720939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-2027384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-2307356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-2759421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-2917714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-295035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-3167975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-3396870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-3791412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-7813020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-7821230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-7896094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-7954812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-8005443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-8431944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-8462848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-8939869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-9056777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-9217163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-9458050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17947428-9823896
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0016-6731
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
177
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1639-54
|
|
pubmed:dateRevised |
2011-10-14
|
|
pubmed:meshHeading |
pubmed-meshheading:17947428-Animals,
pubmed-meshheading:17947428-Base Sequence,
pubmed-meshheading:17947428-Caenorhabditis elegans,
pubmed-meshheading:17947428-Caenorhabditis elegans Proteins,
pubmed-meshheading:17947428-DNA, Helminth,
pubmed-meshheading:17947428-DNA Primers,
pubmed-meshheading:17947428-Disorders of Sex Development,
pubmed-meshheading:17947428-Dosage Compensation, Genetic,
pubmed-meshheading:17947428-Feedback,
pubmed-meshheading:17947428-Female,
pubmed-meshheading:17947428-Genes, Helminth,
pubmed-meshheading:17947428-Male,
pubmed-meshheading:17947428-Models, Genetic,
pubmed-meshheading:17947428-Mutation,
pubmed-meshheading:17947428-RNA Interference,
pubmed-meshheading:17947428-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:17947428-Sex Determination Processes,
pubmed-meshheading:17947428-Sex Differentiation,
pubmed-meshheading:17947428-Signal Transduction,
pubmed-meshheading:17947428-X Chromosome
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Revisiting the X:A signal that specifies Caenorhabditis elegans sexual fate.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
