|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0007320,
umls-concept:C0011900,
umls-concept:C0023418,
umls-concept:C0085973,
umls-concept:C0087111,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1546466,
umls-concept:C1552599,
umls-concept:C1704787
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1992-4-7
|
|
pubmed:abstractText |
A case of intracerebral nodular leukemic mass that developed in a girl eight years after a diagnosis of acute lymphoblastic leukemia (ALL) and 18 months after second discontinuation of therapy for a central nervous system (CNS) relapse is reported. The morphologic picture and the long time that elapsed from the diagnosis raised the suspicion of a cerebral neoplasm; the immediate and dramatic effect of steroid treatment, on the contrary, indicated the presence of a leukemic infiltration and in the meantime, a bone marrow relapse occurred. The patient soon after received high-dose Cytosine Arabinoside (HD ARA C) + Vincristine (VCR) + Levo-Asparaginase (L-ASE) + Prednisone (PDN) without any intrathecal antiblastic drug. We observed a neurological recovery and a complete disappearance of the mass. After consolidation of the remission the patient began an ablative regimen for bone marrow transplantation. The efficacy of HD ARA C in the treatment of the intracerebral nodular leukemic mass is emphasized.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0390-6078
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
76
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
324-6
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1794739-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1794739-Aphasia,
pubmed-meshheading:1794739-Asparaginase,
pubmed-meshheading:1794739-Blood-Brain Barrier,
pubmed-meshheading:1794739-Bone Marrow Transplantation,
pubmed-meshheading:1794739-Brain Neoplasms,
pubmed-meshheading:1794739-Child, Preschool,
pubmed-meshheading:1794739-Combined Modality Therapy,
pubmed-meshheading:1794739-Cranial Irradiation,
pubmed-meshheading:1794739-Cytarabine,
pubmed-meshheading:1794739-Dexamethasone,
pubmed-meshheading:1794739-Female,
pubmed-meshheading:1794739-Humans,
pubmed-meshheading:1794739-Intracranial Pressure,
pubmed-meshheading:1794739-Methotrexate,
pubmed-meshheading:1794739-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:1794739-Prednisone,
pubmed-meshheading:1794739-Remission Induction,
pubmed-meshheading:1794739-Vincristine
|
|
pubmed:articleTitle |
Parenchymal brain leukemia. Case report: problems related to the diagnosis and treatment.
|
|
pubmed:affiliation |
Clinica Pediatrica, Università di Milano, Italy.
|
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
