Linked Life Data

17947148

Source:http://linkedlifedata.com/resource/pubmed/id/17947148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-10-23
pubmed:abstractText
When the same set of genes appear in two top ranking gene lists in two different studies, it is often of interest to estimate the probability for this being a chance event. This overlapping probability is well known to follow the hypergeometric distribution. Usually, the lengths of top-ranking gene lists are assumed to be fixed, by using a pre-set criterion on, e.g., p-value for the t-test. We investigate how overlapping probability changes with the gene selection criterion, or simply, with the length of the top-ranking gene lists. It is concluded that overlapping probability is indeed a function of the gene list length, and its statistical significance should be quoted in the context of gene selection criterion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1557-170X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5531-4
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Overlapping probabilities of top ranking gene lists, hypergeometric distribution, and stringency of gene selection criterion.
pubmed:affiliation
Regeneron Pharmaceutical Inc., Tarrytown, NY 10591, USA. wen.fury@regeneron.com
pubmed:publicationType
Journal Article