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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-10-23
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pubmed:abstractText |
The free energy released during the interaction of the 16S rRNA tail with the mRNA sequence during translation contains a weak sinusoidal pattern of frequency 1/3 cycles/nucleotide. We hypothesize that this signal encodes information related to the maintenance of reading frame during elongation. In the case of the well-studied +1 frameshifter, prfB in E. coli, we have observed a direct relationship between cumulative signal phase and reading frame. Based on this observation, we have developed a model that indicates how likely it is for the ribosome to stay in frame throughout the process of elongation. We validate this model by analyzing verified coding sequences in E. coli.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1557-170X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4540-3
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pubmed:meshHeading |
pubmed-meshheading:17946637-Algorithms,
pubmed-meshheading:17946637-Codon,
pubmed-meshheading:17946637-Escherichia coli,
pubmed-meshheading:17946637-Escherichia coli Proteins,
pubmed-meshheading:17946637-Frameshift Mutation,
pubmed-meshheading:17946637-Models, Genetic,
pubmed-meshheading:17946637-Models, Statistical,
pubmed-meshheading:17946637-Models, Theoretical,
pubmed-meshheading:17946637-Nucleic Acid Hybridization,
pubmed-meshheading:17946637-Open Reading Frames,
pubmed-meshheading:17946637-Peptide Termination Factors,
pubmed-meshheading:17946637-RNA, Messenger,
pubmed-meshheading:17946637-RNA, Ribosomal, 16S,
pubmed-meshheading:17946637-Ribosomes,
pubmed-meshheading:17946637-Signal Processing, Computer-Assisted,
pubmed-meshheading:17946637-Software
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pubmed:year |
2006
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pubmed:articleTitle |
A computational model for reading frame maintenance.
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pubmed:affiliation |
Dept. of Electr. & Comput. Eng., North Carolina State Univ., Raleigh, NC 27695, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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