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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-10-23
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pubmed:abstractText |
Several important non-cardiac drugs have been removed from the market after revealing harmful effect that was not identified during prior safety-assessment studies. We developed a new technique for the measurements of repolarization abnormalities from surface ECGs; this method improves sensitivity and specificity of the current technique used to identify the presence of abnormal ion current kinetics in the myocardial cells namely a prolongation of the QT interval on the surface ECG signal. We described in this paper the method and preliminary results, revealing the superiority of our technique that may play a role in the future of drug-safety assessment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
1557-170X
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pubmed:author |
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|
pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4010-5
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pubmed:meshHeading |
pubmed-meshheading:17946595-Adult,
pubmed-meshheading:17946595-Anti-Infective Agents,
pubmed-meshheading:17946595-Arrhythmias, Cardiac,
pubmed-meshheading:17946595-Aza Compounds,
pubmed-meshheading:17946595-Delayed Rectifier Potassium Channels,
pubmed-meshheading:17946595-Electrocardiography,
pubmed-meshheading:17946595-Female,
pubmed-meshheading:17946595-Humans,
pubmed-meshheading:17946595-Long QT Syndrome,
pubmed-meshheading:17946595-Male,
pubmed-meshheading:17946595-Placebos,
pubmed-meshheading:17946595-Quinolines
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|
pubmed:year |
2006
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pubmed:articleTitle |
Electrocardiographic method for identifying drug-induced repolarization abnormalities associated with a reduction of the rapidly activating delayed rectifier potassium current.
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pubmed:affiliation |
Rochester Univ., NY 14642, USA. heartjpc@heart.rochester.edu
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pubmed:publicationType |
Journal Article
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