Linked Life Data

17942327

Source:http://linkedlifedata.com/resource/pubmed/id/17942327

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-11-20
pubmed:abstractText
Both the ventral and dorsal striatum are involved in various forms of motor, motivational and learning behaviors. Previously, we demonstrated that several striatum-dependent motor and learning behaviors were reduced in mice with increased age. In this study, we investigated the effects of aging on synaptic plasticity in brain slices containing the nucleus accumbens (NAc) or caudate-putamen (CPu), using electrophysiological recordings. We showed that long-term depression (LTD) was reduced or absent in the NAc of aged C57BL/6 mice, whereas the amount of LTD in the CPu of young and aged mice was similar. The LTD induced by 10-Hz stimulation is NMDAR-dependent in the NAc, but NMDAR-independent in the CPu. Our results suggest that NAc LTD may be more sensitive than CPu LTD to the effects of normal aging with a possibility that NMDAR-dependent LTD may be more susceptible to the aging process than non-NMDAR LTD. We also showed that paired-pulse facilitation was diminished in the NAc and CPu in aged mice, suggesting that aging is accompanied by significant decline in presynaptic function in both the ventral and dorsal striata. The age-related reduction in synaptic plasticity may be a cellular mechanism underlying the age-related impairments in striatum-dependent motor and cognitive functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1074-7427
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Differential effect of aging on synaptic plasticity in the ventral and dorsal striatum.
pubmed:affiliation
Department of Pharmacology, Beckman Institute for Advanced Science and Technology, MC-251, University of Illinois at Urbana-Champaign, 405 N. Mathews Avenue, Urbana, IL 61801, USA. ywangy@uiuc.edu
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't