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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-12-7
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pubmed:abstractText |
Type 1 Diabetes Mellitus results from an autoimmune destruction of the pancreatic beta cells, which produce insulin. The lack of insulin leads to chronic hyperglycemia and secondary complications, such as cardiovascular disease. The currently approved clinical treatments for diabetes mellitus often fail to achieve sustained and optimal glycemic control. Therefore, there is a great interest in the development of surrogate beta cells as a treatment for type 1 diabetes. Normally, pancreatic beta cells produce and secrete insulin only in response to increased blood glucose levels. However in many cases, insulin secretion from non-beta cells engineered to produce insulin occurs in a glucose-independent manner. In the present study we engineered liver cells to produce and secrete insulin and insulin secretion can be stimulated via the nitric oxide pathway.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17941991-10037257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17941991-10802714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17941991-11016447,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/MAFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Maf Transcription Factors, Large,
http://linkedlifedata.com/resource/pubmed/chemical/NEUROD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/pancreatic and duodenal homeobox 1...
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pubmed:status |
MEDLINE
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pubmed:issn |
1472-6793
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17941991-Adenoviridae,
pubmed-meshheading:17941991-Animals,
pubmed-meshheading:17941991-Arginine,
pubmed-meshheading:17941991-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:17941991-Biomedical Engineering,
pubmed-meshheading:17941991-Cell Line,
pubmed-meshheading:17941991-Cells, Cultured,
pubmed-meshheading:17941991-Gene Transfer Techniques,
pubmed-meshheading:17941991-Genetic Vectors,
pubmed-meshheading:17941991-Hepatocytes,
pubmed-meshheading:17941991-Homeodomain Proteins,
pubmed-meshheading:17941991-Humans,
pubmed-meshheading:17941991-Insulin,
pubmed-meshheading:17941991-Maf Transcription Factors, Large,
pubmed-meshheading:17941991-Nitric Oxide,
pubmed-meshheading:17941991-Rats,
pubmed-meshheading:17941991-Trans-Activators
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pubmed:year |
2007
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pubmed:articleTitle |
Induction of insulin secretion in engineered liver cells by nitric oxide.
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pubmed:affiliation |
Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, 741 South Limestone, BBSRB, Lexington, KY 40536, USA. latha.muniappan@uky.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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