Linked Life Data

17941052

Source:http://linkedlifedata.com/resource/pubmed/id/17941052

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-27
pubmed:abstractText
The objective of this study was to investigate the possible association of the ABCB1 gene C3435 T polymorphism and the CYP3A5 gene A6986G polymorphism with sirolimus (SRL) trough concentration and dose requirements in Chinese stable renal transplant recipients. Blood samples were collected from 105 healthy volunteers and 50 renal transplant patients, whose polymorphisms of the ABCB1 and CYP3A5 genes were determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Plasma concentrations of SRL were determined with HPLC. The allele frequencies of the ABCB1 mutation in Chinese healthy volunteers and renal transplant recipients were 51.0% and 44.0% (p>0.05), while the allele frequencies of the CYP3A5 mutation were 72.9% and 71.0% (p>0.05). The SRL concentration/dose ratio (C/D) in patients with CYP3A5 (*)3/(*)3 were significantly higher than that of those with (*)1 allele (p<0.05). However, no significant differences were observed between C/D and ABCB1 SNPs (p>0.05). These results confirm that when treated with a SRL-based therapy and low-dose steroids, patients carrying the CYP3A5(*)1 allele required significantly more SRL to achieve adequate blood trough concentrations. In patients with SRL-based therapy, genotyping of the CYP3A5 genes may help to optimize the SRL management in renal transplant recipients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0142-2782
pubmed:author
pubmed:copyrightInfo
2007 John Wiley & Sons, Ltd
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17941052-Adult, pubmed-meshheading:17941052-Analysis of Variance, pubmed-meshheading:17941052-Asian Continental Ancestry Group, pubmed-meshheading:17941052-Chi-Square Distribution, pubmed-meshheading:17941052-Cyclosporine, pubmed-meshheading:17941052-Cytochrome P-450 CYP3A, pubmed-meshheading:17941052-Cytochrome P-450 Enzyme System, pubmed-meshheading:17941052-DNA, pubmed-meshheading:17941052-Dose-Response Relationship, Drug, pubmed-meshheading:17941052-Female, pubmed-meshheading:17941052-Gene Frequency, pubmed-meshheading:17941052-Genotype, pubmed-meshheading:17941052-Humans, pubmed-meshheading:17941052-Immunosuppressive Agents, pubmed-meshheading:17941052-Kidney Transplantation, pubmed-meshheading:17941052-Male, pubmed-meshheading:17941052-Middle Aged, pubmed-meshheading:17941052-P-Glycoprotein, pubmed-meshheading:17941052-Polymerase Chain Reaction, pubmed-meshheading:17941052-Polymorphism, Restriction Fragment Length, pubmed-meshheading:17941052-Polymorphism, Single Nucleotide, pubmed-meshheading:17941052-Sirolimus, pubmed-meshheading:17941052-Tacrolimus
pubmed:year
2008
pubmed:articleTitle
Association study of ABCB1 and CYP3A5 gene polymorphisms with sirolimus trough concentration and dose requirements in Chinese renal transplant recipients.
pubmed:affiliation
Clinical Pharmacology Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. miaolysuzhou@163.com
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't