Linked Life Data

1794103

Source:http://linkedlifedata.com/resource/pubmed/id/1794103

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-4-8
pubmed:abstractText
The present study investigated the effects of acute (1 week) and chronic (8 months) quisqualic (quis) and ibotenic (ibo) acid nucleus basalis (NB) lesions on the biochemical activity of the NB cholinergic system (choline acetyltransferase (ChAT) activity) and on neocortical EEG activity. Cortical ChAT activity of quis or ibo NB-lesioned rats did not recover during an 8-month period. Acute and chronic quis and ibo NB lesions increased EEG slow waves and high voltage spindles. Tacridine, an anticholinesterase, dose-dependently suppressed acute and chronic quis and ibo NB lesion-induced EEG changes. The present results suggest that NB cholinergic neurons do not recover after excitotoxin-induced damage during an 8-month period and that cholinergic neuron loss is importantly involved in the acute and chronic lesion-induced EEG changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
559
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
EEG changes induced by acute and chronic quisqualic or ibotenic acid nucleus basalis lesions are stabilized by tacridine.
pubmed:affiliation
Department of Neurology, University of Kuopio, Finland.
pubmed:publicationType
Journal Article