Linked Life Data

17940877

Source:http://linkedlifedata.com/resource/pubmed/id/17940877

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-7-29
pubmed:abstractText
The experiments were designed to study the glutamate gene expression during epilepsy in adult and hypoxic insult to brain during the neonatal period and the therapeutic role of neuroprotective supplements. We investigated the role of metabotropic glutamate-8 receptor (mGluR8) gene expression in cerebellum during epilepsy and neuroprotective role of Bacopa monnieri extract in epilepsy. We also studied the effect of NMDA receptor 1 (NMDAR1) gene expression during neonatal hypoxia and therapeutic role of glucose, oxygen and epinephrine supplementation. During epilepsy a significant down-regulation (P < 0.01) of mGluR8 gene expression was observed which was up-regulated (P < 0.05) near control level after B. monnieri treatment which is supported by Morris water maze experiment. In hypoxic neonates we observed up-regulation (P < 0.001) of the NMDAR1 gene expression whereas glucose and glucose + oxygen was able to significantly reverse (P < 0.001) the gene expression to near control level when compared to hypoxia and epinephrine treatment which was supported by open field test. Our results showed that B. monnieri treatment to epileptic rats significantly brought the reversal of the down-regulated mgluR8 gene expression toward control level. In neonatal rats, hypoxia induced expressional and functional changes in the NMDAR1 receptors of neuronal cells which is corrected by supplementation of glucose alone or glucose followed by oxygen during the resuscitation to prevent the glutamate related neuronal damage. Thus, the results suggest the clinical significance of corrective measures for epileptic and hypoxic management.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1573-6903
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1663-71
pubmed:meshHeading
pubmed-meshheading:17940877-Adrenergic Agonists, pubmed-meshheading:17940877-Adult, pubmed-meshheading:17940877-Animals, pubmed-meshheading:17940877-Animals, Newborn, pubmed-meshheading:17940877-Anoxia, pubmed-meshheading:17940877-Bacopa, pubmed-meshheading:17940877-Behavior, Animal, pubmed-meshheading:17940877-Brain, pubmed-meshheading:17940877-Epilepsy, pubmed-meshheading:17940877-Epinephrine, pubmed-meshheading:17940877-Gene Expression Regulation, pubmed-meshheading:17940877-Glucose, pubmed-meshheading:17940877-Humans, pubmed-meshheading:17940877-Male, pubmed-meshheading:17940877-Maze Learning, pubmed-meshheading:17940877-Neuroprotective Agents, pubmed-meshheading:17940877-Phytotherapy, pubmed-meshheading:17940877-Plant Extracts, pubmed-meshheading:17940877-Rats, pubmed-meshheading:17940877-Rats, Wistar, pubmed-meshheading:17940877-Receptors, Glutamate, pubmed-meshheading:17940877-Receptors, Metabotropic Glutamate, pubmed-meshheading:17940877-Receptors, N-Methyl-D-Aspartate
pubmed:year
2008
pubmed:articleTitle
Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expression.
pubmed:affiliation
Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, 682022, India. cspaulose@cusat.ac.in
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't