Linked Life Data

17940721

Source:http://linkedlifedata.com/resource/pubmed/id/17940721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-7
pubmed:abstractText
Patients with systemic lupus erythematosus (SLE) are known to have lower heart rate variability and impaired vagal modulation, and right lateral position has been shown to lead to a higher vagal modulation than supine position in healthy subjects and patients with cardiovascular diseases. This study evaluated the effect of disease activity and different recumbent positions on cardiac autonomic nervous modulation by heart rate variability analysis in patients with SLE. Thirty-five female patients with SLE and 33 female controls were enrolled in this study. Electrocardiogram was recorded during supine, left lateral, and right lateral positions for 15 min. Both time and frequency domains heart rate variability measures were calculated. The normalized high-frequency power was used as the index of vagal activity, and the low-/high-frequency power ratio as the index of sympathovagal balance. We found that patients with SLE had lower indices of time domain heart rate variability measures and lower low-frequency power, high-frequency power, and normalized high-frequency power than control subjects. SLE patients with lower serum albumin had lower normalized high-frequency power and higher low-/high-frequency power ratio. In patients with SLE, right lateral position could lead to higher high-frequency power, normalized high-frequency power, and lower low-/high-frequency power ratio than supine position. In addition, the lower the normalized high-frequency power in supine position the patient had, the greater the increase in normalized high-frequency power when the position of the patient was changed from supine to right lateral. Thus, serum albumin level might be used as a potential disease severity index of SLE, and right lateral position can lead to higher vagal modulation and lower sympathetic modulation, renin-angiotensin-aldosterone modulation, and vagal withdrawal than supine position in patients with SLE. Right lateral position can be used as an efficient and physiological vagal enhancer in SLE patients with depressed vagal modulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0770-3198
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-300
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effect of disease activity and position on autonomic nervous modulation in patients with systemic lupus erythematosus.
pubmed:affiliation
Department of Chinese Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung Institute of Technology, Kaohsiung, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't