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rdf:type |
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lifeskim:mentions |
umls-concept:C0017351,
umls-concept:C0023449,
umls-concept:C0034897,
umls-concept:C0040715,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C1314939,
umls-concept:C1415857,
umls-concept:C1522702,
umls-concept:C1538631,
umls-concept:C1709634,
umls-concept:C1825005
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-24
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pubmed:abstractText |
Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed up-regulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69%). This study defines a new subgroup of BCP-ALL characterized by ID4 over-expression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-4971
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pubmed:author |
pubmed-author:AkasakaTakashiT,
pubmed-author:ClaviezAlexanderA,
pubmed-author:DyerMartin J SMJ,
pubmed-author:GeskStefanS,
pubmed-author:HarderLanaL,
pubmed-author:HarrisonChristine JCJ,
pubmed-author:Loraine KarranEE,
pubmed-author:MajidAneelaA,
pubmed-author:MazzulloHelenH,
pubmed-author:MoormanAnthony VAV,
pubmed-author:NagelIngaI,
pubmed-author:RossFionaF,
pubmed-author:RussellLisa JLJ,
pubmed-author:SiebertReinerR,
pubmed-author:StreffordJonathan CJC,
pubmed-author:SugimotoKei-JiKJ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-91
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pubmed:meshHeading |
pubmed-meshheading:17940204-Adolescent,
pubmed-meshheading:17940204-Adult,
pubmed-meshheading:17940204-B-Cell-Specific Activator Protein,
pubmed-meshheading:17940204-Base Sequence,
pubmed-meshheading:17940204-Child,
pubmed-meshheading:17940204-Chromosomes, Human, Pair 14,
pubmed-meshheading:17940204-Chromosomes, Human, Pair 6,
pubmed-meshheading:17940204-Chromosomes, Human, Pair 9,
pubmed-meshheading:17940204-Female,
pubmed-meshheading:17940204-Gene Deletion,
pubmed-meshheading:17940204-Genes, p16,
pubmed-meshheading:17940204-Humans,
pubmed-meshheading:17940204-Immunoglobulin Heavy Chains,
pubmed-meshheading:17940204-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17940204-Inhibitor of Differentiation Proteins,
pubmed-meshheading:17940204-Leukemia, B-Cell,
pubmed-meshheading:17940204-Male,
pubmed-meshheading:17940204-Middle Aged,
pubmed-meshheading:17940204-Molecular Sequence Data,
pubmed-meshheading:17940204-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:17940204-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17940204-Translocation, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
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pubmed:affiliation |
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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