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| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C0314672 | lld:lifeskim |
| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C0037813 | lld:lifeskim |
| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C1516451 | lld:lifeskim |
| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C1514623 | lld:lifeskim |
| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:17938407 | lifeskim:mentions | umls-concept:C0443131 | lld:lifeskim |
| pubmed-article:17938407 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17938407 | pubmed:dateCreated | 2008-1-7 | lld:pubmed |
| pubmed-article:17938407 | pubmed:abstractText | The length and precise linkage of polyubiquitin chains is important for their biological activity. Although other ubiquitin-like proteins have the potential to form polymeric chains their identification in vivo is challenging and their functional role is unclear. Vertebrates express three small ubiquitin-like modifiers, SUMO-1, SUMO-2, and SUMO-3. Mature SUMO-2 and SUMO-3 are nearly identical and contain an internal consensus site for sumoylation that is missing in SUMO-1. Combining state-of-the-art mass spectrometry with an "in vitro to in vivo" strategy for post-translational modifications, we provide direct evidence that SUMO-1, SUMO-2, and SUMO-3 form mixed chains in cells via the internal consensus sites for sumoylation in SUMO-2 and SUMO-3. In vitro, the chain length of SUMO polymers could be influenced by changing the relative amounts of SUMO-1 and SUMO-2. The developed methodology is generic and can be adapted for the identification of other sumoylation sites in complex samples. | lld:pubmed |
| pubmed-article:17938407 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17938407 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17938407 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17938407 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17938407 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17938407 | pubmed:issn | 1535-9476 | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:MannMatthiasM | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:MaticIvanI | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:LamondAngus... | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:HayRonald TRT | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:TathamMichael... | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:MacekBorisB | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:OggStephen... | lld:pubmed |
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| pubmed-article:17938407 | pubmed:author | pubmed-author:SchimmelJoost... | lld:pubmed |
| pubmed-article:17938407 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:17938407 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17938407 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:17938407 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17938407 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17938407 | pubmed:pagination | 132-44 | lld:pubmed |
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| pubmed-article:17938407 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17938407 | pubmed:articleTitle | In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. | lld:pubmed |
| pubmed-article:17938407 | pubmed:affiliation | Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. | lld:pubmed |
| pubmed-article:17938407 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17938407 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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