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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-31
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pubmed:abstractText |
DC-159a yielded MICs of <or=1 mug/ml against 316 strains of both quinolone-susceptible and -resistant pneumococci (resistance was defined as a levofloxacin MIC >or=4 microg/ml). Although the MICs for DC-159a against quinolone-susceptible pneumococci were a few dilutions higher than those of gemifloxacin, the MICs of these two compounds against 28 quinolone-resistant pneumococci were identical. The DC-159a MICs against quinolone-resistant strains did not appear to depend on the number or the type of mutations in the quinolone resistance-determining region. DC-159a, as well as the other quinolones tested, was bactericidal after 24 h at 2x MIC against 11 of 12 strains tested. Two of the strains were additionally tested at 1 and 2 h, and DC-159a at 4x MIC showed significant killing as early as 2 h. Multistep resistance selection studies showed that even after 50 consecutive subcultures of 10 strains in the presence of sub-MICs, DC-159a produced only two mutants with maximum MICs of 1 microg/ml.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-10223932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-10223962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-10382885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-10428910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-10991854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-11083646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-12865398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-1444297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-1608677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-1617050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-1617051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-1617076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-17938194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-7559200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-7768776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-8028618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-8196139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-8559623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-8834881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-9687402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-9797225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17938189-9925527
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-84
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci.
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pubmed:affiliation |
Department of Pathology, Clinical Microbiology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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