| pubmed-article:17937983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17937983 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:17937983 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17937983 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:17937983 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17937983 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:17937983 | pubmed:dateCreated | 2007-11-6 | lld:pubmed |
| pubmed-article:17937983 | pubmed:abstractText | Nitrofuranyl isoxazolines with increased proteolytic stability over nitrofuranyl amides were designed and synthesized leading to discovery of several compounds with potent in vitro anti-tuberculosis activity. However, their in vivo activity was limited by high protein binding and poor distribution. Consequently, a series of non-nitrofuran containing isoxazolines were prepared to determine if the core had residual anti-tuberculosis activity. This led to the discovery of novel isoxazoline 12 as anti-tuberculosis agent with a MIC(90) value of 1.56microg/mL. | lld:pubmed |
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| pubmed-article:17937983 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17937983 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17937983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17937983 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17937983 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:Rakesh | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:MeibohmBerndB | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:LeeRichard... | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:LenaertsAnne... | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:LeeRobin E... | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:Tangallapally... | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:SunDianqingD | lld:pubmed |
| pubmed-article:17937983 | pubmed:author | pubmed-author:BudhaNageshwa... | lld:pubmed |
| pubmed-article:17937983 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17937983 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17937983 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17937983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17937983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17937983 | pubmed:pagination | 6638-42 | lld:pubmed |
| pubmed-article:17937983 | pubmed:dateRevised | 2010-9-29 | lld:pubmed |
| pubmed-article:17937983 | pubmed:meshHeading | pubmed-meshheading:17937983... | lld:pubmed |
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| pubmed-article:17937983 | pubmed:meshHeading | pubmed-meshheading:17937983... | lld:pubmed |
| pubmed-article:17937983 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17937983 | pubmed:articleTitle | Discovery of novel isoxazolines as anti-tuberculosis agents. | lld:pubmed |
| pubmed-article:17937983 | pubmed:affiliation | Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA. | lld:pubmed |
| pubmed-article:17937983 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17937983 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17937983 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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