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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2007-11-6
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pubmed:abstractText |
Nitrofuranyl isoxazolines with increased proteolytic stability over nitrofuranyl amides were designed and synthesized leading to discovery of several compounds with potent in vitro anti-tuberculosis activity. However, their in vivo activity was limited by high protein binding and poor distribution. Consequently, a series of non-nitrofuran containing isoxazolines were prepared to determine if the core had residual anti-tuberculosis activity. This led to the discovery of novel isoxazoline 12 as anti-tuberculosis agent with a MIC(90) value of 1.56microg/mL.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-10425086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-11514170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12213077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12519066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12543692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12625709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12729667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15456272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15544513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15608701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15761925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-16366608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-16527486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-16529927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-17168800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-17346196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-17430225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-7796046
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6638-42
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pubmed:dateRevised |
2010-9-29
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pubmed:meshHeading |
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pubmed:year |
2007
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pubmed:articleTitle |
Discovery of novel isoxazolines as anti-tuberculosis agents.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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