Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2007-11-6
pubmed:abstractText
Nitrofuranyl isoxazolines with increased proteolytic stability over nitrofuranyl amides were designed and synthesized leading to discovery of several compounds with potent in vitro anti-tuberculosis activity. However, their in vivo activity was limited by high protein binding and poor distribution. Consequently, a series of non-nitrofuran containing isoxazolines were prepared to determine if the core had residual anti-tuberculosis activity. This led to the discovery of novel isoxazoline 12 as anti-tuberculosis agent with a MIC(90) value of 1.56microg/mL.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-10425086, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-11514170, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12213077, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12519066, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12543692, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12625709, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-12729667, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15456272, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15544513, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15608701, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-15761925, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-16366608, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-16527486, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-16529927, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-17168800, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-17346196, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-17430225, http://linkedlifedata.com/resource/pubmed/commentcorrection/17937983-7796046
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6638-42
pubmed:dateRevised
2010-9-29
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Discovery of novel isoxazolines as anti-tuberculosis agents.
pubmed:affiliation
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural