Linked Life Data

1793777

Source:http://linkedlifedata.com/resource/pubmed/id/1793777

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-4-7
pubmed:abstractText
The gastro-intestinal tract presents a significant barrier to the efficient absorption of both orally administered metal drugs and dietary essential trace minerals. Absorption can be compromised by competition between alimentary metal ions, by an excess of dietary ligands (e.g. polyphosphates), or by disease (e.g. chronic inflammation). Alternative delivery by injection can be expensive, painful, often promotes systemic toxicity and usually leads to rapid elimination through excretion (bile, urine), as a consequence of bolus dosing. By contrast, our new observations indicate that presenting trace metals or metal drugs in lipophilic forms which can penetrate the dermis, permits their slow release from the skin with more efficient (relative to incipient toxicity) systemic delivery. Examples are given from our own research of dermal application of copper(II), zinc(II), titanium(IV), platinum(II) and gold(I) complexes to treat chronic inflammatory disease. Some of these compounds are also anti-cancer agents. Physical and biological constraints to transdermal (percutaneous) drug delivery are discussed together with some chemical principles governing selection of complexes as metal drugs or dietary supplements.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1055-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-102
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Transdermal delivery of inorganic complexes as metal drugs or nutritional supplements.
pubmed:affiliation
Graduate School of Science and Technology, Bond University, Qld, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't