| pubmed-article:17937396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C2700597 | lld:lifeskim |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C1423884 | lld:lifeskim |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:17937396 | lifeskim:mentions | umls-concept:C1326539 | lld:lifeskim |
| pubmed-article:17937396 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17937396 | pubmed:dateCreated | 2007-10-31 | lld:pubmed |
| pubmed-article:17937396 | pubmed:abstractText | Somites are blocks of mesoderm that form when segment boundaries are periodically generated in the anterior presomitic mesoderm (PSM). Periodicity is thought to be driven by an oscillating Notch-centered segmentation clock, whereas boundaries are spatially positioned by the secreted signaling molecules Wnt3a and Fgf8. We identified the putative transcriptional corepressor Ripply2 as a differentially expressed gene in wild-type and Wnt3a(-/-) embryos. Here, we show that Ripply2 is expressed in the anterior PSM and that it indeed lies downstream of Wnt3a. Dynamic Ripply2 expression in prospective somites S0 and S-I overlaps with the rostral expression of cycling genes in the Notch pathway, suggesting that Ripply2 may be controlled by the segmentation clock. Continued expression of Ripply2 in embryos lacking Hes7, a molecular oscillator in the Notch clock, indicates that Hes7 is not a major regulator of Ripply2. Our data are consistent with Ripply2 functioning as a segment boundary determination gene during mammalian embryogenesis. Developmental | lld:pubmed |
| pubmed-article:17937396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17937396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17937396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17937396 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17937396 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:17937396 | pubmed:author | pubmed-author:DuntyWilliam... | lld:pubmed |
| pubmed-article:17937396 | pubmed:author | pubmed-author:YamaguchiTerr... | lld:pubmed |
| pubmed-article:17937396 | pubmed:author | pubmed-author:BirisKristin... | lld:pubmed |
| pubmed-article:17937396 | pubmed:copyrightInfo | Published 2007 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:17937396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17937396 | pubmed:volume | 236 | lld:pubmed |
| pubmed-article:17937396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17937396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17937396 | pubmed:pagination | 3167-72 | lld:pubmed |
| pubmed-article:17937396 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:17937396 | pubmed:meshHeading | pubmed-meshheading:17937396... | lld:pubmed |
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| pubmed-article:17937396 | pubmed:meshHeading | pubmed-meshheading:17937396... | lld:pubmed |
| pubmed-article:17937396 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17937396 | pubmed:articleTitle | Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis. | lld:pubmed |
| pubmed-article:17937396 | pubmed:affiliation | Cancer and Developmental Biology Laboratory, Center for Cancer Research, NCI-Frederick, NIH, Frederick, Maryland 21702, USA. | lld:pubmed |
| pubmed-article:17937396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17937396 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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