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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-10-31
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pubmed:abstractText |
Somites are blocks of mesoderm that form when segment boundaries are periodically generated in the anterior presomitic mesoderm (PSM). Periodicity is thought to be driven by an oscillating Notch-centered segmentation clock, whereas boundaries are spatially positioned by the secreted signaling molecules Wnt3a and Fgf8. We identified the putative transcriptional corepressor Ripply2 as a differentially expressed gene in wild-type and Wnt3a(-/-) embryos. Here, we show that Ripply2 is expressed in the anterior PSM and that it indeed lies downstream of Wnt3a. Dynamic Ripply2 expression in prospective somites S0 and S-I overlaps with the rostral expression of cycling genes in the Notch pathway, suggesting that Ripply2 may be controlled by the segmentation clock. Continued expression of Ripply2 in embryos lacking Hes7, a molecular oscillator in the Notch clock, indicates that Hes7 is not a major regulator of Ripply2. Our data are consistent with Ripply2 functioning as a segment boundary determination gene during mammalian embryogenesis. Developmental
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Hes7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lfng protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mesp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ripply2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf15 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Uncx4.1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3A Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3a protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1058-8388
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pubmed:author |
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pubmed:copyrightInfo |
Published 2007 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
236
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3167-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17937396-Animals,
pubmed-meshheading:17937396-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:17937396-Embryonic Development,
pubmed-meshheading:17937396-Extracellular Matrix Proteins,
pubmed-meshheading:17937396-Gene Expression Regulation, Developmental,
pubmed-meshheading:17937396-Glycosyltransferases,
pubmed-meshheading:17937396-Homeodomain Proteins,
pubmed-meshheading:17937396-In Situ Hybridization,
pubmed-meshheading:17937396-Mesoderm,
pubmed-meshheading:17937396-Mice,
pubmed-meshheading:17937396-Receptors, Notch,
pubmed-meshheading:17937396-Repressor Proteins,
pubmed-meshheading:17937396-Somites,
pubmed-meshheading:17937396-Wnt Proteins,
pubmed-meshheading:17937396-Wnt3 Protein,
pubmed-meshheading:17937396-Wnt3A Protein
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pubmed:year |
2007
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pubmed:articleTitle |
Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis.
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pubmed:affiliation |
Cancer and Developmental Biology Laboratory, Center for Cancer Research, NCI-Frederick, NIH, Frederick, Maryland 21702, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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