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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-10-16
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pubmed:abstractText |
Recent evidence suggests that the transcription factor, PPARgamma, is an important negative regulator of inflammation. Because studies of murine adipocytes and macrophages implicate IFN-gamma, a key mediator of granuloma formation in sarcoidosis, as a PPARgamma antagonist, we investigated the relationship between PPARgamma and IFN-gamma in bronchoalveolar lavage (BAL) cells of sarcoidosis patients and healthy controls.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1124-0490
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pubmed:author |
pubmed-author:AbrahamSusammaS,
pubmed-author:BarnaBarbara PBP,
pubmed-author:BonfieldTracey LTL,
pubmed-author:CulverDaniel ADA,
pubmed-author:DrazbaJudith AJA,
pubmed-author:FarverCarol FCF,
pubmed-author:JohnNejimoleN,
pubmed-author:KavuruMani SMS,
pubmed-author:MalurAnaghaA,
pubmed-author:RaychaudhuriBaisakhiB,
pubmed-author:ThomassenMary JaneMJ
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-100
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17937104-Biological Markers,
pubmed-meshheading:17937104-Blotting, Western,
pubmed-meshheading:17937104-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17937104-Cells, Cultured,
pubmed-meshheading:17937104-Female,
pubmed-meshheading:17937104-Gene Expression,
pubmed-meshheading:17937104-Humans,
pubmed-meshheading:17937104-Immunohistochemistry,
pubmed-meshheading:17937104-Interferon-gamma,
pubmed-meshheading:17937104-Macrophages, Alveolar,
pubmed-meshheading:17937104-Male,
pubmed-meshheading:17937104-Microscopy, Confocal,
pubmed-meshheading:17937104-Middle Aged,
pubmed-meshheading:17937104-PPAR gamma,
pubmed-meshheading:17937104-Polymerase Chain Reaction,
pubmed-meshheading:17937104-Prognosis,
pubmed-meshheading:17937104-RNA, Messenger,
pubmed-meshheading:17937104-Sarcoidosis, Pulmonary,
pubmed-meshheading:17937104-Severity of Illness Index
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pubmed:year |
2006
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pubmed:articleTitle |
Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma).
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pubmed:affiliation |
Department of Pulmonary, Allergy, and Critical Care Medicine, Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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