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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-21
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pubmed:abstractText |
RNA interference is an endogenous cellular mechanism in which short interfering RNAs (siRNAs) direct the sequence specific degradation of a target mRNA. siRNAs can be synthesized with chemical modifications to increase stability and reduce double-stranded RNA-induced immune responses without affecting their ability to elicit degradation of target mRNA.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1097-6825
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
88-94
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pubmed:meshHeading |
pubmed-meshheading:17936889-Animals,
pubmed-meshheading:17936889-Bone Marrow Cells,
pubmed-meshheading:17936889-Bronchial Hyperreactivity,
pubmed-meshheading:17936889-Disease Models, Animal,
pubmed-meshheading:17936889-Female,
pubmed-meshheading:17936889-Genes, Reporter,
pubmed-meshheading:17936889-Humans,
pubmed-meshheading:17936889-Interleukin-13,
pubmed-meshheading:17936889-Mast Cells,
pubmed-meshheading:17936889-Mice,
pubmed-meshheading:17936889-Mice, Inbred BALB C,
pubmed-meshheading:17936889-RNA, Small Interfering,
pubmed-meshheading:17936889-RNA Interference,
pubmed-meshheading:17936889-Specific Pathogen-Free Organisms,
pubmed-meshheading:17936889-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice.
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pubmed:affiliation |
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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