Source:http://linkedlifedata.com/resource/pubmed/id/17936885
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2007-12-24
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pubmed:abstractText |
This study investigated the possible antidepressant-like and anxiolytic-like effects of diphenyl diselenide, (PhSe)(2) in mice. The involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the antidepressant-like effect was also evaluated. The immobility times in the tail suspension test (TST) and forced swimming test (FST) were reduced by (PhSe)(2) (5-100 mg/kg; oral route, p.o.). The antiimmobility effect of (PhSe)(2) (5 mg/kg, p.o.) in the TST was prevented by pretreatment of mice with L-arginine [a substrate for nitric oxide synthase (NOS)], methylene blue [an inhibitor of NO synthase and sGC] and sildenafil [a phosphodiesterase 5 inhibitor]. Furthermore, a sub-effective dose of (PhSe)(2) (0.1 mg/kg, p.o.) produced a synergistic antidepressant-like effect with N(G)-nitro-L-arginine [L-NNA; 0.3mg/kg, i.p. inhibitor of NOS], (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one [ODQ; 30 pmol/site i.c.v., a specific inhibitor of soluble guanylate cyclase (sGC)], fluoxetine and imipramine in the TST. (PhSe)(2) (50-100 mg/kg, p.o.) induced anxiolytic-like effect in the elevated plus-maze test and light/dark box. Together the results indicate that (PhSe)(2) elicited significant antidepressant-like and anxiolytic-like effects. The antidepressant-like action caused by (PhSe)(2) seems to involve an interaction with L-arginine-NO-cGMP pathway.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzene Derivatives,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Organoselenium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/diphenyldiselenide
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0091-3057
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
418-26
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17936885-Animals,
pubmed-meshheading:17936885-Anti-Anxiety Agents,
pubmed-meshheading:17936885-Antidepressive Agents,
pubmed-meshheading:17936885-Arginine,
pubmed-meshheading:17936885-Benzene Derivatives,
pubmed-meshheading:17936885-Exploratory Behavior,
pubmed-meshheading:17936885-Female,
pubmed-meshheading:17936885-Guanylate Cyclase,
pubmed-meshheading:17936885-Hindlimb Suspension,
pubmed-meshheading:17936885-Male,
pubmed-meshheading:17936885-Mice,
pubmed-meshheading:17936885-Motor Activity,
pubmed-meshheading:17936885-Nitric Oxide,
pubmed-meshheading:17936885-Organoselenium Compounds,
pubmed-meshheading:17936885-Postural Balance,
pubmed-meshheading:17936885-Signal Transduction,
pubmed-meshheading:17936885-Swimming
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pubmed:year |
2008
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pubmed:articleTitle |
Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action.
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pubmed:affiliation |
Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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