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17936624
Source:
http://linkedlifedata.com/resource/pubmed/id/17936624
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0027392
,
umls-concept:C0220781
,
umls-concept:C0243076
,
umls-concept:C0268563
,
umls-concept:C0597357
,
umls-concept:C1333712
,
umls-concept:C1706589
,
umls-concept:C1707455
,
umls-concept:C1883254
pubmed:issue
23
pubmed:dateCreated
2007-11-6
pubmed:abstractText
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Naphthyridines
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate
,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 5
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1464-3405
pubmed:author
pubmed-author:Augelli-SzafranCorinne ECE
,
pubmed-author:BoveSusan ESE
,
pubmed-author:BrookerRachel MRM
,
pubmed-author:ConnollyCleo JCJ
,
pubmed-author:GalatsisPaulP
,
pubmed-author:KilgoreKenneth SKS
,
pubmed-author:KinsoraJack JJJ
,
pubmed-author:KnauerChristopher SCS
,
pubmed-author:MickelsonJohn WJW
,
pubmed-author:MilbankJared B JJB
,
pubmed-author:SchwarzRoy DRD
,
pubmed-author:WendtJohn AJA
,
pubmed-author:YamagataKojiK
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6525-8
pubmed:meshHeading
pubmed-meshheading:17936624-Animals
,
pubmed-meshheading:17936624-CHO Cells
,
pubmed-meshheading:17936624-Cricetinae
,
pubmed-meshheading:17936624-Cricetulus
,
pubmed-meshheading:17936624-Naphthyridines
,
pubmed-meshheading:17936624-Rats
,
pubmed-meshheading:17936624-Receptors, Metabotropic Glutamate
,
pubmed-meshheading:17936624-Stereoisomerism
,
pubmed-meshheading:17936624-Structure-Activity Relationship
pubmed:year
2007
pubmed:articleTitle
Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
pubmed:affiliation
Department of Medicinal Chemistry, Pfizer Global Research & Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.
pubmed:publicationType
Journal Article
,
Comparative Study