| pubmed-article:17935987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C0376565 | lld:lifeskim |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C0332514 | lld:lifeskim |
| pubmed-article:17935987 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:17935987 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:17935987 | pubmed:dateCreated | 2007-11-6 | lld:pubmed |
| pubmed-article:17935987 | pubmed:abstractText | 3-O-3'(or 2')-Methylsuccinyl-betulinic acid (MSB) derivatives were separated by using recycle HPLC. The structures of four isomers were assigned by NMR and asymmetric synthesis. 3-O-3'S-Methylsuccinyl-betulinic acid (3'S-MSB, 4) exhibited potent anti-HIV activity with an EC(50) value of 0.0087microM and a TI value of 6.3x10(3), which is comparable to the data for bevirimat (DSB, PA-457), a current clinical trials drug that was also derived from betulinic acid. The anti-HIV potency of 4 was slightly better than that of AZT. | lld:pubmed |
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| pubmed-article:17935987 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17935987 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17935987 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17935987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17935987 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17935987 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:LeeKuo-Hsiung... | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:Morris-Natsch... | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:KilgoreNicole... | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:YuDongleiD | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:AllawayGraham... | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:Nakagawa-Goto... | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:NitzTheodore... | lld:pubmed |
| pubmed-article:17935987 | pubmed:author | pubmed-author:QianKeduoK | lld:pubmed |
| pubmed-article:17935987 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17935987 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17935987 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17935987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17935987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17935987 | pubmed:pagination | 6553-7 | lld:pubmed |
| pubmed-article:17935987 | pubmed:dateRevised | 2011-4-22 | lld:pubmed |
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| pubmed-article:17935987 | pubmed:meshHeading | pubmed-meshheading:17935987... | lld:pubmed |
| pubmed-article:17935987 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17935987 | pubmed:articleTitle | Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. | lld:pubmed |
| pubmed-article:17935987 | pubmed:affiliation | Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. | lld:pubmed |
| pubmed-article:17935987 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17935987 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17935987 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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