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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2007-11-6
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pubmed:abstractText |
3-O-3'(or 2')-Methylsuccinyl-betulinic acid (MSB) derivatives were separated by using recycle HPLC. The structures of four isomers were assigned by NMR and asymmetric synthesis. 3-O-3'S-Methylsuccinyl-betulinic acid (3'S-MSB, 4) exhibited potent anti-HIV activity with an EC(50) value of 0.0087microM and a TI value of 6.3x10(3), which is comparable to the data for bevirimat (DSB, PA-457), a current clinical trials drug that was also derived from betulinic acid. The anti-HIV potency of 4 was slightly better than that of AZT.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-12076748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-14573704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-15225375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-15353975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-16942019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-1919029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-8176401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-8676334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-8909827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-9459011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-9469816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17935987-9873802
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6553-7
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pubmed:dateRevised |
2011-4-22
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pubmed:meshHeading |
pubmed-meshheading:17935987-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:17935987-Anti-HIV Agents,
pubmed-meshheading:17935987-Cell Line, Tumor,
pubmed-meshheading:17935987-HIV-1,
pubmed-meshheading:17935987-Humans,
pubmed-meshheading:17935987-Stereoisomerism,
pubmed-meshheading:17935987-Structure-Activity Relationship,
pubmed-meshheading:17935987-Succinates,
pubmed-meshheading:17935987-Triterpenes,
pubmed-meshheading:17935987-Virus Replication
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pubmed:year |
2007
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pubmed:articleTitle |
Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.
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pubmed:affiliation |
Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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