Source:http://linkedlifedata.com/resource/pubmed/id/17935071
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2007-10-30
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| pubmed:abstractText |
CD31(+)CD45RA(+)RO(-) lymphocytes contain high numbers of T cell receptor circle (TREC)-bearing T cells; however, the correlation between CD31(+)CD4(+) lymphocytes and TREC during aging and under lymphopenic conditions has not yet been sufficiently investigated. We analyzed TREC, telomere length and telomerase activity within sorted CD31(+) and CD31(-) CD4(+) lymphocytes in healthy individuals from birth to old age. Sorted CD31(+)CD45RA(+)RO(-) naive CD4(+) lymphocytes contained high TREC numbers, whereas CD31(+)CD45RA(-)RO(+) cells (comprising < or =5% of CD4(+) cells during aging) did not contain TREC. CD31(+) overall CD4(+) cells remained TREC rich despite an age-related tenfold reduction from neonatal (100 : 1000) to old age (10 : 1000). Besides a high TREC content, CD31(+)CD45RA(+)RO(-)CD4(+) cells exhibited significantly longer telomeres and higher telomerase activity than CD31(-)CD45RA(+)RO(-)CD4(+) cells, suggesting that CD31(+)CD45RA(+)RO(-)CD4(+) cells represent a distinct population of naive T cells with particularly low replicative history. To analyze the value of CD31 in lymphopenic conditions, we investigated six children after allogeneic hematopoietic stem cell transplantation (HSCT). Reemerging overall CD4(+) as well as naive CD45RA(+)RO(-)CD4(+) cells predominantly expressed CD31 and correlated well with the recurrence of TREC 5-12 months after HSCT. Irrespective of limitations in the elderly, CD31 is an appropriate marker to monitor TREC-rich lymphocytes essentially in lymphopenic children after HSCT.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0014-2980
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| pubmed:author |
pubmed-author:FauchereJean-ClaudeJC,
pubmed-author:GüngörTayfunT,
pubmed-author:GrotzerMichaelM,
pubmed-author:JungeSonjaS,
pubmed-author:KeiskerAndreA,
pubmed-author:Kloeckener-GruissemBarbaraB,
pubmed-author:SalgoBettinaB,
pubmed-author:SchererFranziskaF,
pubmed-author:SegerReinhardR,
pubmed-author:ShalabyTarekT,
pubmed-author:SilerUlrichU,
pubmed-author:ZuffereyRomainR
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| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3270-80
|
| pubmed:meshHeading |
pubmed-meshheading:17935071-Adolescent,
pubmed-meshheading:17935071-Adult,
pubmed-meshheading:17935071-Aged,
pubmed-meshheading:17935071-Aging,
pubmed-meshheading:17935071-Antigens, CD31,
pubmed-meshheading:17935071-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17935071-Child,
pubmed-meshheading:17935071-Child, Preschool,
pubmed-meshheading:17935071-Flow Cytometry,
pubmed-meshheading:17935071-Humans,
pubmed-meshheading:17935071-Infant,
pubmed-meshheading:17935071-Infant, Newborn,
pubmed-meshheading:17935071-Lymphopenia,
pubmed-meshheading:17935071-Middle Aged,
pubmed-meshheading:17935071-Plasmids,
pubmed-meshheading:17935071-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17935071-T-Lymphocyte Subsets,
pubmed-meshheading:17935071-Telomerase,
pubmed-meshheading:17935071-Telomere,
pubmed-meshheading:17935071-Thymus Gland
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children.
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| pubmed:affiliation |
Division of Immunology/Hematology/BMT, University Children's Hospital, Zürich, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|