| pubmed-article:1793464 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1793464 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:1793464 | lifeskim:mentions | umls-concept:C0037173 | lld:lifeskim |
| pubmed-article:1793464 | lifeskim:mentions | umls-concept:C0524909 | lld:lifeskim |
| pubmed-article:1793464 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1793464 | pubmed:dateCreated | 1992-3-23 | lld:pubmed |
| pubmed-article:1793464 | pubmed:abstractText | Four hundred and four patients (273 men, 131 women) aged 3 to 85 years with chronic Hepatitis B virus (HBV) infection seen during a five year period were analysed. At presentation, 177 patients (44%) were Hepatitis B e Antigen (HBeAg) positive (mean age 32 years) and 217 patients (54%) were anti-HBe-positive (mean age 40 years). Ten patients (2%) were negative for HBeAg and anti-HBe. Serum HBV-DNA was detected in 169 patients (42%). 85% of the HBeAg-positive patients had detectable serum HBV-DNA and 9% of the HBeAg-negative patients were positive for serum HBV-DNA. The mean serum Alanine amino-transferase (ALT) and Aspartate amino-transferase (AST) levels were higher in HBeAg-positive patients (75 and 52 iu/l) than in HBeAg negative patients (46 and 37 iu/l) (P less than 0.001). Liver biopsies were performed in 135 patients. Fifty-three (39%) had minimal changes, 61 (45%) chronic hepatitis (CPH, CLH & CAH) and 21 (16%) cirrhosis. There was no significant difference in the histologic distribution between HBeAg-positive and HBeAg-negative groups. Two hundred and fifty eight patients were followed up for a mean duration of 2 years (range 3 to 108 months). The cumulative probability of clearing HBeAg at the end of the first, second and third year were 14%, 16% and 18% respectively. Of these, the cumulative probability of developing anti-HBe over one, two and three years were 8%, 9% and 11% respectively. Reversion to HBeAg occurred in 1.5% of patients who were HBeAg-negative at presentation and 11% of HBeAg-positive patients who cleared HBeAg.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1793464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1793464 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1793464 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1793464 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1793464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1793464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1793464 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1793464 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1793464 | pubmed:issn | 0037-5675 | lld:pubmed |
| pubmed-article:1793464 | pubmed:author | pubmed-author:YaoFF | lld:pubmed |
| pubmed-article:1793464 | pubmed:author | pubmed-author:WehLL | lld:pubmed |
| pubmed-article:1793464 | pubmed:author | pubmed-author:GuanRR | lld:pubmed |
| pubmed-article:1793464 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1793464 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:1793464 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1793464 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1793464 | pubmed:pagination | 352-5 | lld:pubmed |
| pubmed-article:1793464 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:meshHeading | pubmed-meshheading:1793464-... | lld:pubmed |
| pubmed-article:1793464 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1793464 | pubmed:articleTitle | Chronic hepatitis B infection in Singapore. | lld:pubmed |
| pubmed-article:1793464 | pubmed:affiliation | Department of Medicine, National University Hospital, Singapore. | lld:pubmed |
| pubmed-article:1793464 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1793464 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1793464 | lld:pubmed |
