Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-3-23
|
| pubmed:abstractText |
Four hundred and four patients (273 men, 131 women) aged 3 to 85 years with chronic Hepatitis B virus (HBV) infection seen during a five year period were analysed. At presentation, 177 patients (44%) were Hepatitis B e Antigen (HBeAg) positive (mean age 32 years) and 217 patients (54%) were anti-HBe-positive (mean age 40 years). Ten patients (2%) were negative for HBeAg and anti-HBe. Serum HBV-DNA was detected in 169 patients (42%). 85% of the HBeAg-positive patients had detectable serum HBV-DNA and 9% of the HBeAg-negative patients were positive for serum HBV-DNA. The mean serum Alanine amino-transferase (ALT) and Aspartate amino-transferase (AST) levels were higher in HBeAg-positive patients (75 and 52 iu/l) than in HBeAg negative patients (46 and 37 iu/l) (P less than 0.001). Liver biopsies were performed in 135 patients. Fifty-three (39%) had minimal changes, 61 (45%) chronic hepatitis (CPH, CLH & CAH) and 21 (16%) cirrhosis. There was no significant difference in the histologic distribution between HBeAg-positive and HBeAg-negative groups. Two hundred and fifty eight patients were followed up for a mean duration of 2 years (range 3 to 108 months). The cumulative probability of clearing HBeAg at the end of the first, second and third year were 14%, 16% and 18% respectively. Of these, the cumulative probability of developing anti-HBe over one, two and three years were 8%, 9% and 11% respectively. Reversion to HBeAg occurred in 1.5% of patients who were HBeAg-negative at presentation and 11% of HBeAg-positive patients who cleared HBeAg.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0037-5675
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
352-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1793464-Adolescent,
pubmed-meshheading:1793464-Adult,
pubmed-meshheading:1793464-Aged,
pubmed-meshheading:1793464-Aged, 80 and over,
pubmed-meshheading:1793464-Biopsy,
pubmed-meshheading:1793464-Child,
pubmed-meshheading:1793464-Child, Preschool,
pubmed-meshheading:1793464-Chronic Disease,
pubmed-meshheading:1793464-DNA, Viral,
pubmed-meshheading:1793464-Female,
pubmed-meshheading:1793464-Follow-Up Studies,
pubmed-meshheading:1793464-Hepatitis B,
pubmed-meshheading:1793464-Hepatitis B e Antigens,
pubmed-meshheading:1793464-Hepatitis B virus,
pubmed-meshheading:1793464-Humans,
pubmed-meshheading:1793464-Male,
pubmed-meshheading:1793464-Middle Aged,
pubmed-meshheading:1793464-Singapore
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Chronic hepatitis B infection in Singapore.
|
| pubmed:affiliation |
Department of Medicine, National University Hospital, Singapore.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|