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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2007-11-6
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pubmed:abstractText |
Various 4-phenylpiperidine-benzoxazin-3-ones were synthesized and biologically evaluated as urotensin-II (U-II) receptor antagonists. Compound 12i was identified from in vitro evaluation as a low nanomolar antagonist against both rat and human U-II receptors. This compound showed in vivo efficacy in reversing the ear-flush response induced by U-II in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AlmondHarold RHRJr,
pubmed-author:DamianoBruce PBP,
pubmed-author:GhoshShyamaliS,
pubmed-author:HaertleinBarbaraB,
pubmed-author:KinneyWilliam AWA,
pubmed-author:LawsonEdward CEC,
pubmed-author:LiJianJ,
pubmed-author:LuciDiane KDK,
pubmed-author:MaryanoffBruce EBE,
pubmed-author:MinorLisa KLK,
pubmed-author:ParryTom JTJ,
pubmed-author:QiJensonJ,
pubmed-author:SmithCharles ECE,
pubmed-author:WangYuanpingY
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
6489-92
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pubmed:meshHeading |
pubmed-meshheading:17933531-Animals,
pubmed-meshheading:17933531-Benzoxazines,
pubmed-meshheading:17933531-CHO Cells,
pubmed-meshheading:17933531-Cricetinae,
pubmed-meshheading:17933531-Cricetulus,
pubmed-meshheading:17933531-Humans,
pubmed-meshheading:17933531-Piperidines,
pubmed-meshheading:17933531-Rats,
pubmed-meshheading:17933531-Receptors, G-Protein-Coupled,
pubmed-meshheading:17933531-Structure-Activity Relationship,
pubmed-meshheading:17933531-Urotensins
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pubmed:year |
2007
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pubmed:articleTitle |
Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.
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pubmed:affiliation |
Research & Early Development, Johnson & Johnson Pharmaceutical Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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