|
pubmed:abstractText |
Nitroglycerine (GTN) is an organic nitrate that has been used for more than 100 years. Despite its widespread clinical use, several aspects of the pharmacology of GTN remain elusive. In a recent study, the authors of the present study showed that GTN causes opening of the mitochondrial permeability transition pore (mPTP) and mitochondrial production of reactive oxygen species (ROS).
|
|
pubmed:affiliation |
Department of Internal, Cardiovascular and Geriatric Medicine, University of Siena, Italy, and Department of Medicine, Mount Sinai and University Health Network Hospitals, Toronto, Ontario, Canada.
|
