Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2007-10-31
pubmed:abstractText
Tau is an axonal microtubule-associated protein involved in microtubule assembly and stabilization. Mutations in Tau cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and tau aggregates are present in Alzheimer's disease and other tauopathies. The mechanisms leading from tau dysfunction to neurodegeneration are still debated. The dynein-activator complex dynactin has an essential role in axonal transport and mutations in its gene are associated with lower motor neuron disease. We show here for the first time that the N-terminal projection domain of tau binds to the C-terminus of the p150 subunit of the dynactin complex. Tau and dynactin show extensive colocalization, and the attachment of the dynactin complex to microtubules is enhanced by tau. Mutations of a conserved arginine residue in the N-terminus of tau, found in patients with FTDP-17, affect its binding to dynactin, which is abnormally distributed in the retinal ganglion cell axons of transgenic mice expressing human tau with a mutation in the microtubule-binding domain. These findings, which suggest a direct involvement of tau in axonal transport, have implications for understanding the pathogenesis of tauopathies.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-10226031, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-11520930, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-11921059, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-12062019, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-12325083, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-12417659, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-12505985, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-12627231, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-12650922, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-12789661, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-1465130, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-15096589, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-15130579, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-15140937, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-15381688, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-15473859, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-15852399, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-16126385, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-16240349, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-16697405, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-17187063, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-17449914, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-1828535, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-2034137, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-2124967, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-2484340, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-3139677, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-7518465, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-7878030, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-8432362, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-8522593, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-8795614, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-9015267, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-9144527, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-9342383, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-9428770, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-9751880, http://linkedlifedata.com/resource/pubmed/commentcorrection/17932487-9824291
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1460-2075
pubmed:author
pubmed:issnType
Electronic
pubmed:day
31
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4546-54
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Interaction of tau protein with the dynactin complex.
pubmed:affiliation
Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't