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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2007-11-6
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pubmed:abstractText |
A new series of non-peptidic, mono-acid protein tyrosine phosphatase 1B (PTP1B) inhibitors has been identified by structure-based design. Compounds with 2-(indol-3-yl)- and 2-phenyl-3,3,3-trifluoro-2-hydroxypropionic acid core units targeted at the enzyme's primary site and a hydrophobic chlorophenylthiazole extension in its 2 degrees site exhibit 3-60microM IC(50)s for PTP1B inhibition in an Sf9 cell-based assay.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AbrahamAchammaA,
pubmed-author:AdamsDavid RDR,
pubmed-author:AsanoJunJ,
pubmed-author:BreslinCatherineC,
pubmed-author:DickColin A JCA,
pubmed-author:IxkesUlrichU,
pubmed-author:JohnstonBlair FBF,
pubmed-author:JohnstonDerekD,
pubmed-author:KewnayJustinJ,
pubmed-author:MacKenzieSimon JSJ,
pubmed-author:MackaySimon PSP,
pubmed-author:McFarlaneMoragM,
pubmed-author:MitchellLeeL,
pubmed-author:SpinksDanielD,
pubmed-author:TakanoYasuoY
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
6579-83
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pubmed:meshHeading |
|
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pubmed:year |
2007
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pubmed:articleTitle |
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.
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pubmed:affiliation |
Department of Chemistry, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK. D.R.Adams@hw.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study
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