In this study, we asked whether a possible quantitative or qualitative deficiency in naturally occurring Foxp3(+)CD4(+) regulatory T-cells (nT(reg)), which display potent inhibitory effects on T-cell functions in vitro and in vivo, may predispose to the development of type 1 diabetes.
Department of Microbiology and Immunology, McGill Center for the Study of Host Resistance, McGill University, 3775 University St., Room 510, Lyman Duff Medical Building, Montreal, QC, Canada.
