Linked Life Data

17927952

Source:http://linkedlifedata.com/resource/pubmed/id/17927952

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-10-26
pubmed:abstractText
MafA is a basic leucine zipper (b-Zip) type transcription factor that binds to the insulin promoter and regulates insulin transcription synergistically with Pdx-1 and NeuroD. Transforming growth factor-beta (TGF-beta) signaling has been reported to regulate activity of b-Zip transcription factor such as ATF-2 and acts as an important regulator of insulin gene transcription and pancreatic beta cell maintenance. To investigate the relationship between MafA-dependent transcriptional activation and TGF-beta signaling, we examined the effects of TGF-beta signal on MafA-dependent transactivation of the rat insulin II gene promoter (RIPII-251) and a synthetic MafA-dependent promoter. MafA-dependent activation of the reporters was inhibited in the presence of Smad2/Smad4 or Smad3/Smad4 and a constitutively active TGF-beta type I receptor and this inhibition was dependent upon the presence of MafA. Co-immunoprecipitation analyses revealed that MafA physically interacts with Smad2 or Smad3. These results suggest that MafA-dependent transcriptional activation is negatively regulated by TGF-beta signaling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1090-2104
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
364
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Suppression of MafA-dependent transcription by transforming growth factor-beta signaling.
pubmed:affiliation
Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
pubmed:publicationType
Journal Article