|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0026336,
umls-concept:C0026882,
umls-concept:C0030705,
umls-concept:C0033105,
umls-concept:C0086409,
umls-concept:C0086930,
umls-concept:C0220825,
umls-concept:C0376571,
umls-concept:C0598034,
umls-concept:C0679560,
umls-concept:C1879774
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|
pubmed:issue |
29
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|
pubmed:dateCreated |
2007-10-10
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|
pubmed:abstractText |
The BRCAPRO model, used to predict a family's likelihood of carrying a BRCA1 or BRCA2 mutation, was designed using mutation frequencies of white and Ashkenazi Jewish populations, and may not be applicable to other populations. BRCAPRO was recently validated in African Americans, although has yet to be examined in Hispanics. This retrospective study reports the mutation frequency and spectrum of BRCA1 and BRCA2 mutations in a Hispanic population and evaluates the BRCAPRO model in Hispanics.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Oct
|
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pubmed:issn |
1527-7755
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:day |
10
|
|
pubmed:volume |
25
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
4635-41
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pubmed:meshHeading |
pubmed-meshheading:17925560-Adult,
pubmed-meshheading:17925560-Aged,
pubmed-meshheading:17925560-Breast Neoplasms,
pubmed-meshheading:17925560-Female,
pubmed-meshheading:17925560-Genes, BRCA1,
pubmed-meshheading:17925560-Genes, BRCA2,
pubmed-meshheading:17925560-Hispanic Americans,
pubmed-meshheading:17925560-Humans,
pubmed-meshheading:17925560-Middle Aged,
pubmed-meshheading:17925560-Mutation,
pubmed-meshheading:17925560-Ovarian Neoplasms,
pubmed-meshheading:17925560-Prevalence,
pubmed-meshheading:17925560-ROC Curve,
pubmed-meshheading:17925560-Risk,
pubmed-meshheading:17925560-United States
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model.
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pubmed:affiliation |
Center for Medical Genetics, Evanston Northwestern Healthcare, Evanston, IL, USA.
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pubmed:publicationType |
Journal Article
|
