| pubmed-article:17925453 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C1882854 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C1879985 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C0178666 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C1556156 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C0679083 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:17925453 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:17925453 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17925453 | pubmed:dateCreated | 2007-12-10 | lld:pubmed |
| pubmed-article:17925453 | pubmed:abstractText | In vivo calorie restriction [CR; consuming 60% of ad libitum (AL) intake] induces elevated insulin-stimulated glucose transport (GT) in skeletal muscle. The mechanisms triggering this adaptation are unknown. The aim of this study was to determine whether physiological reductions in extracellular glucose and/or insulin, similar to those found with in vivo CR, were sufficient to elevate GT in isolated muscles. Epitrochlearis muscles dissected from rats were incubated for 24 h in media with glucose (8 mM) and insulin (80 microU/ml) at levels similar to plasma values of AL-fed rats and compared with muscles incubated with glucose (5.5 mM) and/or insulin (20 microU/ml) at levels similar to plasma values of CR rats. Muscles incubated with CR levels of glucose and insulin for 24 h had a subsequently greater (P < 0.005) GT with 80 microU/ml insulin and 8 mM [(3)H]-3-O-methylglucose but unchanged GT without insulin. Reducing only glucose or insulin for 24 h or both glucose and insulin for 6 h did not induce altered GT. Increased GT after 24-h incubation with CR levels of glucose and insulin was not attributable to increased insulin receptor tyrosine phosphorylation, Akt serine phosphorylation, or Akt substrate of 160 kDa phosphorylation. Nor did 24-h incubation with CR levels of glucose and insulin alter the abundance of insulin receptor, insulin receptor substrate-1, GLUT1, or GLUT4 proteins. These results provide the proof of principle that reductions in extracellular glucose and insulin, similar to in vivo CR, are sufficient to induce an increase in insulin-stimulated glucose transport comparable to the increase found with in vivo CR. | lld:pubmed |
| pubmed-article:17925453 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17925453 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17925453 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17925453 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17925453 | pubmed:issn | 0193-1849 | lld:pubmed |
| pubmed-article:17925453 | pubmed:author | pubmed-author:AriasEdward... | lld:pubmed |
| pubmed-article:17925453 | pubmed:author | pubmed-author:CarteeGregory... | lld:pubmed |
| pubmed-article:17925453 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17925453 | pubmed:volume | 293 | lld:pubmed |
| pubmed-article:17925453 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17925453 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17925453 | pubmed:pagination | E1782-8 | lld:pubmed |
| pubmed-article:17925453 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:17925453 | pubmed:meshHeading | pubmed-meshheading:17925453... | lld:pubmed |
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| pubmed-article:17925453 | pubmed:meshHeading | pubmed-meshheading:17925453... | lld:pubmed |
| pubmed-article:17925453 | pubmed:meshHeading | pubmed-meshheading:17925453... | lld:pubmed |
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| pubmed-article:17925453 | pubmed:meshHeading | pubmed-meshheading:17925453... | lld:pubmed |
| pubmed-article:17925453 | pubmed:meshHeading | pubmed-meshheading:17925453... | lld:pubmed |
| pubmed-article:17925453 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17925453 | pubmed:articleTitle | In vitro simulation of calorie restriction-induced decline in glucose and insulin leads to increased insulin-stimulated glucose transport in rat skeletal muscle. | lld:pubmed |
| pubmed-article:17925453 | pubmed:affiliation | Division of Kinesiology, Univ. of Michigan, 401 Washtenaw Ave., Ann Arbor, MI 48109, USA. edarias@umich.edu | lld:pubmed |
| pubmed-article:17925453 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17925453 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
