|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
25
|
|
pubmed:dateCreated |
1976-8-2
|
|
pubmed:abstractText |
The authors have followed the effects of application of the deposit estradiolbenzoat on the blood lipides level of women at the beginning of menopause and women with arteriosclerosis. They have registered a moderate drop of the concentration of cholesterol, beta-lipoproteins, and slight changes of the non-esterified fatty acids level. Women using contraceptive hormonal mixtures were found with higher level of cholesterol in the blood serum than those being watched. The application of a single dose of androgen did not have any substantial effects on the blood lipides level.
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Androgens--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Comparative Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female--side...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estradiol Benzoate--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Estradiol Benzoate--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hematological Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Hemic System,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/LIPIDS,
http://linkedlifedata.com/resource/pubmed/keyword/Lipid Metabolic Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Menopause,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Combined,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies
|
|
pubmed:language |
ger
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Hormonal,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0044-4197
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
97
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1574-9
|
|
pubmed:dateRevised |
2008-2-11
|
|
pubmed:otherAbstract |
PIP: Previous studies of blood lipid levels in women after removal of the ovaries indicate that changes in the lipoprotein spectrum set in soon after the operation, probably due to the sudden lack of estrogen. An investigation was undertaken to determine the best method of supplying the hormone. Both short- and long-term intake of estrogen were studied, with 20 regular contraceptive users representing long-term application. A 1-time dose of estradiol benzoate tended to slightly decrease cholesterol level in 50 early-menopausal women and markedly decreased cholesterol and beta-lipoprotein levels in a sample of 15 menopausal, arteriosclerotic women. A 1-time application of androgen had no significant effect on the blood lipids of 12 menopausal women. Cholesterol levels of 22 oral contraceptive users corresponded in general with those of a control group, but were slightly lower; differences between the 2 groups' beta-lipoprotein and fatty acid levels were insignificant. Previous studies have indicated that arteriosclerosis and myocardial infarction in older and sterilized women are related to lack of estrogen; however, results of estrogen therapy have not always been satisfactory. The results of this study suggest that estradiol benzoate is a suitable substitute for ovarian estrogen in sterilized patients; it has also proven useful in treating menopausal complaints. The study also sheds some light on the influence of hormonal contraceptives on lipid metabolism; estrogen preparations decrease the cholesterol and beta-lipoprotein levels without influencing concentration of the ester-free fatty acids, whereas estrogen-progesterone combinations lead to a clear rise in cholesterol level in the blood serum. The next stage of the ongoing work will be to investigate the effect of other hormones, including progesterone itself, on metabolism of the lipids.
|
|
pubmed:meshHeading |
pubmed-meshheading:179252-Adult,
pubmed-meshheading:179252-Cholesterol,
pubmed-meshheading:179252-Contraceptives, Oral, Hormonal,
pubmed-meshheading:179252-Estradiol,
pubmed-meshheading:179252-Estrogens,
pubmed-meshheading:179252-Fatty Acids, Nonesterified,
pubmed-meshheading:179252-Female,
pubmed-meshheading:179252-Humans,
pubmed-meshheading:179252-Lipids,
pubmed-meshheading:179252-Lipoproteins, LDL,
pubmed-meshheading:179252-Menopause
|
|
pubmed:year |
1975
|
|
pubmed:articleTitle |
[Effects of estrogenic hormones on blood lipids].
|
|
pubmed:publicationType |
Journal Article,
English Abstract
|
