Linked Life Data

17924143

Source:http://linkedlifedata.com/resource/pubmed/id/17924143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-12-6
pubmed:abstractText
Clonorchis sinensis, which causes clonorchiasis, is of major socioeconomic importance in China. In this study, we report the use of CotC, a major component of the Bacillus subtilis spore coat, as a fusion partner for the expression of C. sinensis TP20.8 (Tegumental Protein 20.8 kDa) on the spore coat. Western blotting was used to identify TP20.8 surface expression on spores. Recombinant spores displaying the TP20.8 antigen were used for oral immunization and were shown to generate mucosal response in rats. TP20.8-specific secretory IgA in feces reached significant levels 2 weeks after oral dosing. This report shows that surface display of recombinant C. sinensis TP20.8 on B. subtilis spores was immunogenic and B. subtilis spores can be used as a mucosal immunization vehicle for parasite prevention and control.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0932-0113
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Immunogenicity of recombinant Bacillus subtilis spores expressing Clonorchis sinensis tegumental protein.
pubmed:affiliation
Guangzhou Women And Children's Medical Center, Guangzhou Medical College, 318 Renminzhong road, Guangzhou, 510120, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't