| pubmed-article:17923086 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17923086 | lifeskim:mentions | umls-concept:C0020962 | lld:lifeskim |
| pubmed-article:17923086 | lifeskim:mentions | umls-concept:C0009324 | lld:lifeskim |
| pubmed-article:17923086 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:17923086 | lifeskim:mentions | umls-concept:C1420610 | lld:lifeskim |
| pubmed-article:17923086 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17923086 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17923086 | pubmed:dateCreated | 2007-10-9 | lld:pubmed |
| pubmed-article:17923086 | pubmed:abstractText | Inflammatory bowel disease (IBD) has been attributed to overexuberant host immunity or the emergence of harmful intestinal flora. The transcription factor T-bet orchestrates inflammatory genetic programs in both adaptive and innate immunity. We describe a profound and unexpected function for T-bet in influencing the behavior of host inflammatory activity and commensal bacteria. T-bet deficiency in the innate immune system results in spontaneous and communicable ulcerative colitis in the absence of adaptive immunity and increased susceptibility to colitis in immunologically intact hosts. T-bet controls the response of the mucosal immune system to commensal bacteria by regulating TNF-alpha production in colonic dendritic cells, critical for colonic epithelial barrier maintenance. Loss of T-bet influences bacterial populations to become colitogenic, and this colitis is communicable to genetically intact hosts. These findings reveal a novel function for T-bet as a peacekeeper of host-commensal relationships and provide new perspectives on the pathophysiology of IBD. | lld:pubmed |
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| pubmed-article:17923086 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17923086 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17923086 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17923086 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17923086 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:MazmanianSark... | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:GlimcherLauri... | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:ItoSusumuS | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:GlickmanJonat... | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:LordGraham... | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:Lugo-Villarin... | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:GarrettWendy... | lld:pubmed |
| pubmed-article:17923086 | pubmed:author | pubmed-author:PunitShiveshS | lld:pubmed |
| pubmed-article:17923086 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17923086 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:17923086 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:17923086 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17923086 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17923086 | pubmed:pagination | 33-45 | lld:pubmed |
| pubmed-article:17923086 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:17923086 | pubmed:meshHeading | pubmed-meshheading:17923086... | lld:pubmed |
| pubmed-article:17923086 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17923086 | pubmed:articleTitle | Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. | lld:pubmed |
