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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-10-9
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pubmed:abstractText |
Inflammatory bowel disease (IBD) has been attributed to overexuberant host immunity or the emergence of harmful intestinal flora. The transcription factor T-bet orchestrates inflammatory genetic programs in both adaptive and innate immunity. We describe a profound and unexpected function for T-bet in influencing the behavior of host inflammatory activity and commensal bacteria. T-bet deficiency in the innate immune system results in spontaneous and communicable ulcerative colitis in the absence of adaptive immunity and increased susceptibility to colitis in immunologically intact hosts. T-bet controls the response of the mucosal immune system to commensal bacteria by regulating TNF-alpha production in colonic dendritic cells, critical for colonic epithelial barrier maintenance. Loss of T-bet influences bacterial populations to become colitogenic, and this colitis is communicable to genetically intact hosts. These findings reveal a novel function for T-bet as a peacekeeper of host-commensal relationships and provide new perspectives on the pathophysiology of IBD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-11336164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-11352068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-11994418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-12434060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-12876555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-1460426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-14671975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-14766966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15260992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15472509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15489957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15516924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15654823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15752557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15785758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15790844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15885120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-15948242,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-16311599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-16497592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-16760749,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-16922084,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-17361131,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17923086-9682004
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-45
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:17923086-Animals,
pubmed-meshheading:17923086-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17923086-Colitis, Ulcerative,
pubmed-meshheading:17923086-Colon,
pubmed-meshheading:17923086-DNA-Binding Proteins,
pubmed-meshheading:17923086-Dendritic Cells,
pubmed-meshheading:17923086-Female,
pubmed-meshheading:17923086-Gene Expression Regulation,
pubmed-meshheading:17923086-Humans,
pubmed-meshheading:17923086-Immunity, Innate,
pubmed-meshheading:17923086-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:17923086-Intestinal Mucosa,
pubmed-meshheading:17923086-Mice,
pubmed-meshheading:17923086-Mice, Knockout,
pubmed-meshheading:17923086-T-Box Domain Proteins,
pubmed-meshheading:17923086-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.
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