|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008838,
umls-concept:C0013216,
umls-concept:C0014939,
umls-concept:C0025723,
umls-concept:C0205195,
umls-concept:C0205210,
umls-concept:C0205225,
umls-concept:C0332120,
umls-concept:C0376358,
umls-concept:C0936012,
umls-concept:C1527178,
umls-concept:C1705938,
umls-concept:C2699007
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|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2008-1-31
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|
pubmed:abstractText |
To determine whether oestrogen enhances platinum sensitivity, and if promoter CpG methylation of the oestrogen receptor-alpha (ER-alpha) gene determines the potential of cisplatin-induced apoptosis in prostate cancer, as the high-mobility group 1 (HMG1) preferentially binds to cisplatin-modified DNA and is up-regulated after oestrogen treatment in breast cancer cell line MCF-7.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1464-410X
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:volume |
101
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
485-91
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pubmed:meshHeading |
pubmed-meshheading:17922863-Aged,
pubmed-meshheading:17922863-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17922863-Blotting, Western,
pubmed-meshheading:17922863-Cisplatin,
pubmed-meshheading:17922863-Estrogen Receptor alpha,
pubmed-meshheading:17922863-Estrogens,
pubmed-meshheading:17922863-Humans,
pubmed-meshheading:17922863-Male,
pubmed-meshheading:17922863-Methylation,
pubmed-meshheading:17922863-Polymerase Chain Reaction,
pubmed-meshheading:17922863-Prostatic Neoplasms,
pubmed-meshheading:17922863-Sensitivity and Specificity,
pubmed-meshheading:17922863-Tumor Cells, Cultured
|
|
pubmed:year |
2008
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|
pubmed:articleTitle |
Rationale and clinical implication of combined chemotherapy with cisplatin and oestrogen in prostate cancer: primary evidence based on methylation analysis of oestrogen receptor-alpha.
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|
pubmed:affiliation |
Department of Urology, Shimane University School of Medicine, Izumo, Japan. gonda-n@med.shimane-u.ac.jp
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pubmed:publicationType |
Journal Article
|
